neuropathy

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Neuropathy of haematopoietic stem cell niche is essential fo

标签：文库时间：2024-12-15

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LETTER

doi:10.1038/nature13383

Neuropathyofhaematopoieticstemcellnicheisessentialformyeloproliferativeneoplasms

′nchez-Aguilera1,DanielMart?′n-Pe′rez1,JoanIsern1,XavierLanga1,AlexandarTzankov2,LorenaArranz1,AbelSa

′n3,Yi-ShiuanTzeng4,Dar-MingLai4,Ju¨rgSchwaller2,RadekC.Skoda2PontusLundberg2,SandraMuntio

′nMe′ndez-Ferrer1&Simo

Myeloproliferativeneoplasms(MPNs)arediseasescausedbymuta-tionsinthehaematopoieticstemcell(HSC)compartment.MostMPNpatientshaveacommonacquiredmutationofJanuskinase2(JAK2)geneinHSCs1–4thatrendersthiskinaseconst

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