联合检测低密度脂蛋白和C反应蛋白在不同类型冠心病中的临床价值

联合检测低密度脂蛋白和Ｃ反应蛋白在不同类型冠心病中的临床价

值

【摘要】 目的 通过检测低密度脂蛋白(LDL-C)和C反应蛋白(CRP)在不同类型冠心病中的浓度，探讨LDL-C和CRP与稳定型心绞痛(SAP)、不稳定型心绞痛(UAP)及急性心肌梗死(AMI)的关系。方法 入选冠心病患者92例，分为三组，SAP组36例；UAP组30例； AMI组26例；对照组26例。同时测定LDL-C和CRP浓度。结果 ①冠心病组LDL-C显著高于对照组;② AMI组、UAP组、SAP组CRP显著高于对照组，AMI组、UAP组CRP高于SAP组;③LDL-C未达标组CRP高于LDL-C达标组。结论 联合检测LDL-C和CRP的水平可以判断冠心病的严重程度，对冠心病的诊断和治疗均有重要的参考价值。

【Abstract】 Objective To investigate the possible relation between the levels of low-density lipoprotein(LDL-C)and C-reactive protein(CRP)in patients with diferent types of coronary heart disease.Methods The levels ofLDL-C and CRP were measured and compared in 92 subjects included36 with stable angina pectoris(SAP),30 with unstable angina pectoris(UAP),26 with acute myocardialinfarction(AMI)and 26 control subjects to evaluate the relationship betweenLDL-C and CRP.Results ①The level of LDL-C in patients with CHD was significantly higher than those in the control subjects.②The levels of CRP in patients with CHD,including SAP.UAP and AMI,were significantly higher than those in the control subjects,but the of CRP in patients with UAP and AMI were higher than those in SAP.③The level of CRP in patients with the level ofLDL-C target met were higher than those in patients with the level ofLDL-C target not met.Conclusion Joint detection of LDL-C and CRP may be helpful to assessing danger degree of coronary heart disease.

【Key words】Low-density lipoprotein； C-reactive protein

冠心病是临床常见多发疾病，冠状动脉内粥样斑块形成是冠心病的发病基础，多数学者认为血脂异常与冠心病有明显关系，特别是低密度脂蛋白胆醇(low density lipoprotein cholesterol，LDL-C)升高被认为是最主要的、独立的危险因素，降脂的首要目标是降低LDL-C的水平，并使之达标，减少由冠心病引起的病死率、病残率以及相关事件。但是临床检测显示并不是所有的冠心病患者血脂都升高，只有1/2的人表现为血脂异常[1]，越来越多的资料表明以C反应蛋白(C-re

active protein，CRP)为标志的炎症反应在粥样血栓的形成及发展中起关键作用。笔者在不同类型的冠心病患者中同时检测了LDL-C和CRP水平，特别是对不同LDL-C水平上对比了CRP浓度的变化，旨在探讨联合检测LDL-C和CRP在不同类型冠心病患者中的临床价值。

1 资料与方法

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