弥散张量成像评估亚低温治疗弥漫性轴索损伤的优势

SICENCE新闻发布作者：荆国杰稿号：NRR_3_14

弥散张量成像评估亚低温治疗弥漫性轴索损伤的优势

有研究表明，亚低温疗法治疗重型脑损伤有效，弥漫性轴索损伤是为重型颅脑损伤的主要类型之一。那么亚低温治疗弥漫性轴索损伤是否同样有疗效呢？弥散张量成像中的各向异性分数值可定量脑损伤时神经纤维的一致性，使用弥散张量成像定量评估弥漫性轴索损伤疗效的研究报告仍未出现。中国惠州市第一人民医院荆国杰所在课题组进行的一项研究显示，弥散张量成像可以作为定量评估弥漫性轴索损伤的指标，亚低温组平均疗效在神经轴索损伤程度恢复方面约为常温组的1.32-1.36倍。由此作者认为，弥散张量成像能评估亚低温疗法对弥漫性轴索损伤的治疗效果。文章发表在《中国神经再生研究（英文版）》杂志2014年1月第2期。

弥散张量成像检测显示，亚低温治疗后，弥散性轴索损伤患者脑各项异向分数图中可见损伤病灶（圆圈部分）缩小

Article: " Mild hypothermia for treatment of diffuse axonal injury: a quantitative analysis of diffusion tensor imaging," by Guojie Jing1, 2, Xiaoteng Yao1, 2, Yiyi Li1, 2, Yituan Xie1, 2, Wangan Li1, 2, Kejun Liu1, 2, Yingchao Jing1, 2, Baisheng Li3, Yifan Lv1, 2, Baoxin Ma1, 2 (1 Department of Neurosurgery, H uizhou Firs t People’s

H ospital, H uizhou 516000, Guangdong Provinc e, C hina; 2H uizhou Neuros urgery I nstitute, H uizhou 516000, Guangdong P rovince, China; 3Department of Neuros urgery, H uizhou C entral P eople’s H ospital, H uizhou 516000, Guangdong P rovinc e, C hina)

Jing GJ, Yao XT, Li YY, Xie YT, Li WG, Liu KJ, Jing YC, Li BS, Lv YF, Ma BX . Mild hypothermia for treatment of diffuse axonal injury: a quantitativ e analysis of diffusion tensor imaging. Neural Regen Res. 2014;9(2):190-197.

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SICENCE新闻发布作者：荆国杰稿号：NRR_3_14 Mild hypothermia for treatment of diffuse axonal injury: a quantitative DTI analysis

Mild hypother mia has been shown to exert appar ent neur oprotective effects in animal models of diffuse axonal inj ury. However, the clinic al effic acy of mild hypother m ia is c ontroversial. Thus, a noninvasive, accur ate, and objective tec hnique is urgently r equired to verify the effect of m ild hypother mia in diffuse axonal injury and its pr ognosis. Fractional anisotr opy values in diffusion tensor imaging (DTI) c an quantitatively r eflect the c onsistency of nerve fibers after br ain damage, wher e higher values gener ally indic ate less damage to nerve fiber s. Ther efor e, Guojie Jing and co-worker s fr om Huizhou First People’s Hospital in China hypothesized that DTI c ould be used to evaluate the effect of mild hypother m ia on diffuse axonal injury. In their study, fr actional anisotr opy value served as an indic ator for quantitative assessment of d iffuse axonal inj ury severity and postoperative r ec overy. They found the differ enc e in aver age fractional anisotropy value for each region of inter est befor e and after mild hypothermia was 1.32–1.36 times higher than the value in the nor mother m ia group. Quantitative assessment of DTI indicates that mild hypother m ia therapy may be beneficial for patients with diffuse axonal injury. The r elevant findings have been published in the Neural Regeneration Research (Vol. 9, No. 2, 2014).

Diffusion tensor imaging showed that lesions wer e reduc ed and fr actional anisotr opy values decr eased in patients with diffuse axonal inj ury after m ild hypother m ia ther apy c ompar ed with nor mother m ia ther apy.

Article: " Mild hypothermia for treatment of diffuse axonal injury: a quantitative analysis of diffusion tensor imaging," by Guojie Jing1, 2, Xiaoteng Yao1, 2, Yiyi Li1, 2, Yituan Xie1, 2, Wangan Li1, 2, Kejun Liu1, 2, Yingchao Jing1, 2, Baisheng Li3, Yifan Lv1, 2, Baoxin Ma1, 2 (1 Department of Neurosurgery, H uizhou Firs t People’s

H ospital, H uizhou 516000, Guangdong Provinc e, C hina; 2H uizhou Neuros urgery I nstitute, H uizhou 516000, Guangdong P rovince, China; 3Department of Neuros urgery, H uizhou C entral P eople’s H ospital, H uizhou 516000, Guangdong P rovinc e, C hina)

Jing GJ, Yao XT, Li YY, Xie YT, Li WG, Liu KJ, Jing YC, Li BS, Lv YF, Ma BX . Mild hypothermia for treatment of diffuse axonal injury: a quantitativ e analysis of diffusion tensor imaging. Neural Regen Res. 2014;9(2):190-197.

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