布美他尼抑制脊神经元钠钾氯联合转运蛋白1的功能实现镇痛

SICENCE新闻发布 作者：何雁冰 稿号：NRR_58_14

布美他尼抑制脊神经元钠钾氯联合转运蛋白1的功能实现镇痛

以往研究结果提示，钠钾氯联合转运蛋白1和钾氯联合转运蛋白2，参与脊髓水平的疼痛传导调控，可通过调节疼痛通路神经元的氯离子浓度影响神经元兴奋性和疼痛敏化。中国南方医科大学珠江医院何雁冰博士所在团队发现，足底切割损伤后大鼠脊髓神经元钠钾氯联合转运蛋白1表达上调，钾氯联合转运蛋白2表达下调。作者推测，鞘内布美他尼可能通过抑制脊神经元钠钾氯联合转运蛋白1的功

文章发表在《中国神经再生研究（英文版）》杂志2014年5月第10期。能从而发挥对切割痛的镇痛效应。

免疫荧光染色显示，大鼠足底切开后钾氯联合转运蛋白2在腰4-5节段脊髓同侧背角深层表达减少

Article: \

sodium-potassium-chloride co-transporter 1 and potassium-chloride co-transporter 2 expression in a rat model of incisional pain,\ (1 Department of

Anesthesiology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China; 2 Department of Anesthesiology and Pain Medicine, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong Province, China)

He YB, Xu SY, Huang JJ, Gong QJ. Analgesic effect of intrathecal bumetanide is accompanied by changes in spinal sodium-potassium-chloride co-transporter 1 and potassium-chloride co-transporter 2 expression in a rat model of incisional pain. Neural Regen Res. 2014;9(10):1055-1062.

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Neural Regen Res

SICENCE新闻发布 作者：何雁冰 稿号：NRR_58_14

Intrathecal bumetanide has analgesic effects through inhibition of NKCC1

Accumulating evidence has demonstrated that the sodium-potassium-chloride co-transporter 1 (NKCC1) and potassium-chloride co-transporter 2 (KCC2) have a role in the modulation of pain transmission at the spinal level through chloride regulation in the pain pathway and by effecting neuronal excitability and pain sensitization. Dr. Yanbing He Zhujiang Hospital, Southern Medical University, China and his team found that intrathecal bumetanide could increase NKCC1 expression and decrease KCC2 expression in spinal cord neurons of rats with incisional pain. The authors presumed that intrathecal bumetanide has analgesic effects on incisional pain through inhibition of NKCC1. This paper was published in Neural Regeneration Research (Vol. 9, No. 10, 2014).

Immunofluorescent staining reveals that potassium-chloride co-transporter 2 expression decreases in the deep laminae of ipsilateral dorsal horn of L4-5 spinal cor after incision.

Article: \

sodium-potassium-chloride co-transporter 1 and potassium-chloride co-transporter 2 expression in a rat model of incisional pain,\ (1 Department of

Anesthesiology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China; 2 Department of

Anesthesiology and Pain Medicine, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong Province, China)

He YB, Xu SY, Huang JJ, Gong QJ. Analgesic effect of intrathecal bumetanide is accompanied by changes in spinal sodium-potassium-chloride co-transporter 1 and potassium-chloride co-transporter 2 expression in a rat model of incisional pain. Neural Regen Res. 2014;9(10):1055-1062.

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