瑞舒伐他汀在急性冠脉综合征患者PCI术后临床疗效观察

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瑞舒伐他汀在急性冠脉综合征患者PCI术后临床疗效观察

作者:黄宇翔 魏芝宝 徐雄生 来源:《中国实用医药》2016年第16期

【摘要】 目的 观察瑞舒伐他汀对急性冠状动脉(冠脉)综合征(ACS)患者经皮冠状动脉介入治疗(PCI)术后的临床疗效。方法 108例接受PCI治疗的ACS患者, 随机分为A、B、C三组, 各36例。A组

术前每晚口服40 mg阿托伐他汀, 术后每晚口服20 mg, 连续服用6个月;B组术前每晚口服40 mg辛伐他汀, 术后每晚口服20 mg, 连续服用6个月;C组术前每晚口服20 mg瑞舒伐他汀, 术后每晚口服10 mg, 连续服用6个月。观察三组治疗前后血脂水平及心肌酶谱水平的变化情况。结果 C组治疗后血脂水平及心肌酶谱水平下降程度均明显优于A组和B组, 差异具有统计学意义(P

【关键词】 瑞舒伐他汀;急性冠状动脉综合征;经皮冠状动脉介入治疗;血脂;心肌酶 DOI:10.14163/j.cnki.11-5547/r.2016.16.001

【Abstract】 Objective To observe clinical effect by rosuvastatin after percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS) patients. Methods A total of 108 ACS patients who received PCI were randomly divided into groups A, B and C, with 36 cases in each group. Group A received preoperative oral administration of 40 mg atorvastatin and postoperative 20 mg for 6 months; group B received preoperative oral administration of 40 mg simvastatin and postoperative 20 mg for 6 months; group C received preoperative oral administration of 20 mg rosuvastatin and postoperative 10 mg for 6 months. Changes of blood lipid and myocardial enzyme levels before and after treatment were observed in all groups. Results After treatment, group C had more obvious blood lipid and myocardial enzyme declined levels than groups A and B, and their difference had statistical significance (P

【Key words】 Rosuvastatin; Acute coronary syndrome; Percutaneous coronary intervention; Blood lipid; Myocardial enzyme

ACS是心内科较为常见的危重症, 其发生与冠状动脉斑块不稳定性有直接关系。目前临床多数患者首选PCI治疗。研究表明, 患者PCI术前、术后早期服用他汀类药物能够显著降低心血管事件的发生率[1, 2]。他汀类药物不仅具有良好的降脂作用, 并且有明显抗动脉粥样硬化的效应, 同时还起到抗炎和抗氧化作用[3]。本研究对本院接受PCI术的ACS患者进行

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