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Prevalence of food hypersensitivity in 0-24months old infants in Chongqing HU Yan £¬LI Haiqi.Department of Primary Child Care £¬Children's Hospital £¬Chongqing University of Medical Sciences £¬400014£¬China.

¡¾Abstract ¡¿Objective Food hypersensitivity is perhaps the most controversial area of clinical

immunology.Owing to the knowledge deficiency about pathogenesis and method of diagnosis £¬the

¡°true ¡±prevalence of food hypersensitivity is still unknown.The present study was designed to estimate the prevalence of food hypersensitivity in 0～24months old infants in Chongqing and to confirm the clinical symptoms in order to diagnose and prevent this disease.Methods International standard method was used to diagnose food hypersensitivity.First £¬a questionnaire £¬skin prick test and elimination test were used as the elementary method to screen the study

subjects

£»if the results of all the three tests were positive £¬food challenge were done to confirm food hypersensitivity.Totally 314normal infants and youny children £¨0-24months old £©from Department of Primary Child Care £¬Children's Hospital £¬Chongqing University of Medical Sciences seen during May and June £¬1999were recruited in this study.Among them £¬250were younger than 12months and 64were 12-24months old.Results

Among the 314subjects £¬304£¨96.8%£©responded to the tests £»43

£¨about 13.7%£©were reported to have food hypersensitivity by their parents £»11subjects were confirmed to have food hypersensitivity by food challenge and 10subjects dropped out due to various causes during the procedure of elimination test.The minimum prevalence of

food hypersensitivity is about 3.5%£¨11/314£©

.On the bases of an assumption that the prevalence of food hypersensitivity was equal in participants and dropouts £¬a best estimate of prevalence was 5.2%.While the prevalence of food hypersensitivity in 0-12months old infants was about 6.1%.The age of all patients confirmed to

have food hypersensitivity was less than 12months £¨average £º6.4±1.8months £©a nd the most susceptible age was

4-6months.Although the offending foods involve soy £¬peanut £¬fish and orange £¬egg and cow's milk were the most

common foods to induce food hypersensitivity.The clinical responses related to cutaneous £¨eczema and wheal £©

£¬gastrointestinal

£¨vomit and diarrhea £©and respiratory £¨sneezing £©symptoms.Conclusion The prevalence of food hypersensitivity in 0-24months old infants was about 5.2%and 0-12months old infants were more susceptible to food hypersensitivity £»the clinical manifestations of food hypersensitivity depend on the target organ affected.Cutaneous £¬gastrointestinal and respiratory symptoms were the most common clinical responses £»The medical history and various in vivo tests are useful.However £¬food challenge is absolutely necessary for diagnosing food hypersensitivity.The only effective treatment for food hypersensitivity is avoidance of the offending food £»prolonging breast feeding may decrease the incidence of food hypersensitivity.

¡¾Key words ¡¿Food hypersensitivity £»Epidemiology £»Prevalence

¡¤

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