对比FDA和CFDA批准的抗癌药物列表

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对比FDA和CFDA批准的抗癌药物列表。

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发现事实。下面的都是FDA批准的靶点药，而有中文名称的是CFDA允许在国内销售的。

可以说，国内病人基本享受不到自从05年以来的绝大多数抗癌研究成果。为父亲大人学习相关知识。

AgentTarget(s)FDA-approved indication(s)CFDA approved

Ado-trastuzumab emtansine

HER2 (ERBB2/neu)

(Kadcyla)

EGFR (HER1/ERBB1), HER2

Afatinib (Gilotrif)

(ERBB2/neu)

Aldesleukin (Proleukin)

Alemtuzumab (Campath) Axitinib (Inlyta) Belimumab (Benlysta) Belinostat (Beleodaq) Bevacizumab (Avastin)

Bortezomib (Velcade) [1] |

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CD52

KIT, PDGFRβ, VEGFR1/2/3 BAFF HDAC VEGF ligand Proteasome

21 substitution (L858R) mutations) Renal cell carcinoma Melanoma

B-cell chronic lymphocytic leukemia Renal cell carcinoma Lupus erythematosus Peripheral T-cell lymphoma Cervical cancer

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Colorectal cancer Fallopian tube cancer Glioblastoma

Non-small cell lung cancer Ovarian cancer Peritoneal cancer Renal cell carcinoma Multiple myeloma

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Non-small cell lung cancer (with EGFR exon 19 deletions or exon

Breast cancer (HER2+)

Bosutinib (Bosulif) Brentuximab vedotin

ABL CD30

Mantle cell lymphoma

Chronic myelogenous leukemia (Philadelphia chromosome positive) Hodgkin lymphoma

Anaplastic large cell lymphoma Medullary thyroid cancer

(Adcetris)

Cabozantinib (Cometriq)

VEGFR2

Canakinumab (Ilaris)

Carfilzomib (Kyprolis)

IL-1β Proteasome

Juvenile idiopathic arthritis

Cryopyrin-associated periodic syndromes Multiple myeloma

FLT3, KIT, MET, RET,

Ceritinib (Zykadia) Cetuximab (Erbitux)

Crizotinib (Xalkori) Dabrafenib (Tafinlar) Dasatinib (Sprycel)

Denosumab (Xgeva) Erlotinib (Tarceva)

Everolimus (Afinitor)

Gefitinib (Iressa) Ibritumomab tiuxetan

ALK

EGFR (HER1/ERBB1) ALK, MET BRAF ABL RANKL

EGFR (HER1/ERBB1) mTOR

Non-small cell lung cancer (with ALK fusion) Colorectal cancer (KRAS wild type)

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Squamous cell cancer of the head and neck Non-small cell lung cancer (with ALK fusion) Melanoma (with BRAF V600 mutation)

Chronic myelogenous leukemia (Philadelphia chromosome positive) Acute lymphoblastic leukemia (Philadelphia chromosome positive) Giant cell tumor of the bone Non-small cell lung cancer

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Pancreatic cancer

Pancreatic neuroendocrine tumor Renal cell carcinoma

Nonresectable subependymal giant cell astrocytoma associated with

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tuberous sclerosis

EGFR (HER1/ERBB1)

(limited approval)

CD20

(Zevalin)

Ibrutinib (Imbruvica) |

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BTK

Mantle cell lymphoma

Non-Hodgkin's lymphoma

Breast cancer (HR+, HER2-)

Non-small cell lung cancer with known prior benefit from gefitinib

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Idelalisib (Zydelig)

Imatinib (Gleevec)

Ipilimumab (Yervoy) Lapatinib (Tykerb)

PI3Kδ

KIT, PDGFR, ABL

Chronic lymphocytic leukemia Chronic lymphocytic leukemia

Follicular B-cell non-Hodgkin lymphoma Small lymphocytic lymphoma GI stromal tumor (KIT+) Dermatofibrosarcoma protuberans

Multiple hematologic malignancies including Philadelphia

chromosome-positive ALL and CML

CTLA-4

HER2 (ERBB2/neu), EGFR

Breast cancer (HER2+)

(HER1/ERBB1)

Chronic myelogenous leukemia (Philadelphia chromosome

Nilotinib (Tasigna) Obinutuzumab (Gazyva) Ofatumumab (Arzerra,

CD20

HuMax-CD20)

Panitumumab (Vectibix) Pazopanib (Votrient)

EGFR (HER1/ERBB1) VEGFR, PDGFR, KIT

Colorectal cancer (KRAS wild type) Renal cell carcinoma Melanoma

Breast cancer (HER2+)

Chronic lymphocytic leukemia

ABL

positive)

CD20

Chronic lymphocytic leukemia

囊 尼洛替尼胶

Melanoma

Pembrolizumab (Keytruda) PD-1 Pertuzumab (Perjeta)

HER2 (ERBB2/neu)

Ponatinib (Iclusig)

Ramucirumab (Cyramza) ABL, FGFR1-3, FLT3, VEGFR2 Chronic myelogenous leukemia VEGFR2

Acute lymphoblastic leukemia (Philadelphia chromosome positive) Gastric cancer or Gastroesophageal junction (GEJ) adenocarcinoma

Regorafenib (Stivarga)

Rituximab (Rituxan, Mabthera)

Romidepsin (Istodax)

Ruxolitinib (Jakafi) Siltuximab (Sylvant) Sipuleucel-T (Provenge) Sorafenib (Nexavar)

Temsirolimus (Torisel) Tocilizumab (Actemra)

Tofacitinib (Xeljanz) Tositumomab (Bexxar) Trametinib (Mekinist) Trastuzumab (Herceptin)

Vandetanib (Caprelsa)

Vemurafenib (Zelboraf) Vismodegib (Erivedge) Vorinostat (Zolinza) Ziv-aflibercept (Zaltrap)

KIT, PDGFRβ, RAF, RET,

VEGFR1/2/3 CD20

HDAC JAK1/2 IL-6

VEGFR, PDGFR, KIT, RAF mTOR IL-6R JAK3 CD20 MEK

HER2 (ERBB2/neu)

EGFR (HER1/ERBB1), RET,

VEGFR2

BRAF

PTCH, Smoothened HDAC

PIGF, VEGFA/B

Colorectal cancer

Gastrointestinal stromal tumors Non-Hodgkin’s lymphoma

Chronic lymphocytic leukemia Rheumatoid arthritis

Granulomatosis with polyangiitis Cutaneous T-cell lymphoma Peripheral T-cell lymphoma Myelofibrosis

Multicentric Castleman's disease Prostate cancer

Hepatocellular carcinoma

Renal cell carcinoma Thyroid carcinoma Renal cell carcinoma Rheumatoid arthritis

Juvenile idiopathic arthritis Rheumatoid arthritis Non-Hodgkin's lymphoma

Melanoma (with BRAF V600 mutation) Breast cancer (HER2+)

Gastric cancer (HER2+) Medullary thyroid cancer

Melanoma (with BRAF V600 mutation) Basal cell carcinoma Cutaneous T-cell lymphoma Colorectal cancer

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