胃癌肿瘤标志物在手术前后检测临床意义的表达

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胃癌肿瘤标志物在手术前后检测临床意义的表达

作者:金凤玛 袁志超 杨树成 陈健 来源:《中外医学研究》2014年第31期

【摘要】 目的:探讨胃癌患者手术前后血清中CEA、CA125、CA242、CA72- 4、CA19-9值的变化,以评估手术疗效中的应用价值。方法:入组胃癌患者40例,检测患者手术前、后血清中CEA、CA125、CA242、CA72-4、CA19-9的高低,进行同一患者手术前后结果对照。结果:胃癌根治术后患者血清CEA、CA125、CA242、CA72- 4、CA19-9值明显低于手术前(P<0.05),而仅行姑息性手术的患者血清CEA、CA125、CA242、CA72- 4、CA19-9值与术前相比差异无统计学意义(P>0.05)。结论:胃癌患者血清CEA、CA125、CA242、CA72- 4、CA19-9存在高水平表达,可用于胃癌手术疗效及预后情况的评估。 【关键词】 胃癌; 血清; 肿瘤标志物

中图分类号 R735.2 文献标识码 B 文章编号 1674-6805(2014)31-0072-03

Clinical Significance of the Variation of Tumor Marker of Cancer Before And After

Opration/JIN Feng-ma,YUAN Zhi-chao,YANG Shu-cheng,et al.//Chinese and Foreign Medical Research,2014,12(31):72-74

【Abstract】 Objective:To investigate the serum levels of CEA,CA125,CA242,CA72- 4,CA19-9 of patients with gastric cancer before and after operation and their significance in evaluate operation effect.Method:Detecting the serum CEA,CA125,CA242,CA72-4,CA19-9 levels in the 40 cases of gastric cancer before and after operation,and making statistic analysis of them.Result:The serum CEA,CA125,CA242,CA72-4,CA19-9 levels in the patients with gastric cancer after radical operation were lower than those before operation(P<0.05).But the variation wasn’t observed after palliative operation(P>0.05).Conclusion:The serum levels of CEA,CA125,CA242,CA72-4,CA19-9 are high of patients with gastric cancer,their detection can be used to evaluate the efficacy of operation for gastric cancer. 【Key words】 Gastric cancer; Serum; Tumor marker

First-author’s address:The Second People’s Hospital of Yancheng City,Yancheng 224003,China

我国胃癌的发病病例处逐年上升趋势,胃癌肿瘤标志物的检测在诊断和手术前后疗效评估有重要意义,40岁以上的人群体检时,常规查CEA对恶性肿瘤高发地区的筛选,有一定的参考价值,血清肿瘤标志物近年来不仅被用于恶性肿瘤的早期诊断,还被用于治疗效果的评估

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