杨梦苏教授1984年毕业于厦门大学，1988年获得加拿大

简介

杨梦甦教授1984年毕业于厦门大学化学系，1993年获得加拿大多伦多大学博士学位，1993-1994期间在美国加州生物医学机构Scripps Research Institute从事研究工作。1994年底加入香港城市大学，现任香港城市大学生物及化学系讲座教授和香港城市大学深圳生物医药中心主任，并兼任英国中兰开夏大学、浙江大学、解放军第三军医大学、沈阳药科大学、及解放军总医院客座教授。在行政工作方面担任香港城市大学校董会荣誉学位委员会、大学顾问委员会、大学教务会、研究生院理事会等多个委员会成员。

杨教授主要研究领域为生物芯片技术的开发与应用和纳米生物领域的基础与应用研究, 1995年迄今成功获得包括国家高科技发展计划（863计划）、香港特区政府创新科技基金和研究资助局、及香港赛马会基金等逾6千万港元研究基金的资助，负责管理多个大型科研项目，亦是香港特区政府大学资助委员会之“药物发现与合成分子技术研究”、“中药基础研究与开发”、“海洋环境研究与创新技术”三个卓越学科的主要成员之一。迄今在国际权威杂志共发表论文160余篇，专著章节17篇，在国内核心杂志发表论文50余篇，在大型国际会议共发表论文80余篇，应邀在各大学和研究机构做过逾70场学术报告，在相关领域申请/获得20多项中国及美国专利。杨教授实验室已培训18名博士、8名硕士及16名博士后。

杨教授为香港特区政府创新科技基金评审委员会和健康防护基金评审委员会成员，及香港特区政府创新科技署纳米技术和先进材料研究院(NAMI)技术顾问，并兼任英国皇家化学会专业

杂志《The Analyst》和中国化学会专业杂志《生命科学仪器》编辑委员会成员，德国《Microchimica Acta》国际顾问委员会成员，以及国际生物芯片大会学术委员会和世界华人高科技化学大会学术委员会成员。杨教授从2002年主持筹建香港城市大学深圳生物医药中心，领导该中心成功获得包括国家高科技发展计划（863）课题及广东省科技重点攻关项目的资助，并得到深圳市/广东省政府的多次奖励，被授予深圳市生物芯片重点实验室的称号。杨教授曾获1996年欧亚化学大会最佳论文奖、2001年亚太肿瘤生物学大会最佳论文奖、2003年王寛诚教育基金会杰出学者奖、2004年清华大学“教育部春晖学者计划”高级访问教授、及2006年深圳创新科技奖。

杨教授为香港城市大学附属港龙生物科技有限公司创办人之一，该公司以创新DNA诊断技术获得2006年香港工商业奖-科技成就大奖，为香港首家获得此荣誉的高校附属公司及生物科技企业。

Representative Publications (since 2005)

I. Biochip Technology 1.

Shen, D.; Kang, Q.; Huang, M.; Zhang, H.; Yang, M. S. “Equivalent circuit model and impedance analysis for the fine response characteristics to liquid viscodensity for a piezoelectric quartz crystal sensor with longitudinal wave effect”, Analytica Chimica Acta, 2005, 551(1-2), 15-22.

Li, C. W.; Yang, J.; Tzang, C. H.; Zhao, J.; Yang, M. S. “Using thermally printed transparency as photomasks to generate microfluidic structures in PDMS material”, Sensors and Actuators A: Physical, 2006, 126, 463-468.

Yi; C.; Li, C. W.; Yang, M. S. “Microfluidics technology for manipulation and analysis of biological cells”, Analytica Chimica Acta, 2006, 560, 1-23.

Yang, M. S.; Tsoi, P. Y.; Li, C. W.; Zhao, J. “Analysis of interactions of template/primer duplexes with T7 DNA polymerase by oligonucleotide microarray”, Sensors and Actuators B: Chemical, 2006, 115, 428-433. Yi, C.; Zhang, Q.; Li, C. W.; Yang, J.; Zhao, J.; Yang, M. S. “Optical and electrochemical detection techniques for cell-based microfluidic systems,” Analytical and Bioanalytical Chemistry, 2006, 384, 1259-1268.

Li, C.-W.; Chen, R. S. Yang, M. S. “Generation of linear and non-linear concentration gradients along microfluidic channel by microtunnel controlled stepwise addition of sample solution”, Lab on a Chip, 2007, 7, 1371 - 1373,

Li, C. W.; Yang, M. S. “3-D streamline steering by nodes arrayed in an entangled microfluidic network”, Lab on a Chip, 2007, 7, 1712 – 1716.

Wu, L.; Zhang, Q.; Su, L.; Huang, M. H.; Zhao, J. L.; Yang, M. S. “Effects of small molecular inhibitors on the binding between HIV-1 reverse transcriptase and DNA as revealed by SPR biosensor”, Sensors and Actuators B: Chemical, 2007, 122, 243-252.

Li, X. L.; Huang, M. H.; Cao, H. M.; Zhao, J. L.; Yang, M. S. “Study of low molecular weight effectors on the binding between cell membrane receptor IGF-1R and its substrate protein IRS-1 by SPR biosensor”, Sensors and Actuators B: Chemical, 2007, 124, 227-236.

Xu, T.; Li, C. W.; Yao, X. S.; Cai, G. P.; Yang, M. S. “Microfluidic formation of single cell array for parallel analysis of CRAC channel activation and inhibition”, Analytical Biochemistry, 2010, 396, 173-179.

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Zhang, H.; Xu, T.; Yang, M. S. “A microfluidic device with microbead array for sensitive virus DNA detection and genotyping using quantum dots as fluorescence labels”, Biosensors & Bioelectronics, 2010, 25, 2402-2407.

Xu, T.; Li, C. W.; Yao, X. S.; Cai, G. P.; Yang, M. S. “Real-time monitoring of cell-cell communications evoked by mechanical stimulation of suspension cells using an integrated microfluidics chip”, Lab on a Chip, accepted.

II. Nanobiotechnology 1. 2. 3. 4.

Chen, W.; Tzang, L. C. H.; Yang, M. S.; Lee, S. T. \carbon nanotubes: synthesis and characterization,\Applied Physics Letters, 2005, 86, 103114.

Chen, W.; Yao, H.; Tzang, C.-H.; Zhu, J.; Yang, M. S.; Lee, S.-T. “Silicon nanowires for high-sensitivity glucose detection”, Applied Physics Letters, 2006, 88(21), 213104.

Yao, H.; Yi, C. Q.; Tzang, C. H.; Zhu, J. J.; Yang, M. S. “DNA-directed self-assembly of gold nanoparticles into binary and ternary nanostructures”, Nanotechnology, 2007, 18, 015102 (7 pages).

Chan, C.; Tzang, C. H.; Sin; K. K.; Ji; S. L.; Cheung, K. Y.; Tam, T. K.; Yang, M. S.; Renneberg, R.; Seydack, M. ”Biofunctional organic nanocrystals for quantitative detection of pathogen deoxyribonucleic Acid”, Analytica Chimica Acta, 2007, 584, 7-11.

Yi, C. Q.; Fong, C. C.; Chen, W. W.; Qi, S. J.; Tzang, C. H.; Lee, S. T.; Yang, M. S. “Interactions between carbon nanotubes and DNA polymerase and restriction endonucleases”, Nanotechnology, 2007, 18, 025102 (6 pages).

Qi, S. J.; Yi, C. Q.; Chen, W. W.; Lee, S. T.; Yang, M. S. “Effect of silicon nanowires on HepG2 adhesion and spreading”, ChemoBioChem, 2007, 8, 1115-1118.

Yi, C.-Q.; Fong, C. C.; Chen, W.-W.; Qi, S.-J.; Lee, S. T.; Yang, M. S. “Inhibition of biochemical reactions by silicon nanowires through modulating enzyme activities”, ChemoBioChem, 2007, 8, 1225-1229.

Zhang, D. W.; Yi, C. Q.; Zhang, J. C.; Yang, M. S. “The effects of carbon nanotubes on the proliferation and differentiation of primary osteoblasts”, Nanotechnology, 2007, 18, pp475102 (9 pages).

Zhang, M. L.; Yi, C. Q.; Fan, X.; Peng, K.Q.; Wong, N. B.; Yang, M. S.; Zhang, R. Q.; Lee, S. T. “A surface-enhanced Raman spectroscopy substrate for highly sensitive label-free immunoassay”, Applied Physics Letters, 2008, 92, pp043116 (3 pages).

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Yi, C. Q.; Fong, C. C.; Zhang, Q.; Lee, S. T.; Yang, M. S. “The structure and function of ribonuclease A upon interacting with carbon nanotubes”, Nanotechnology, 2008, 19 (9), 095102 (5 pages).

Qi, S. J.; Yi, C. Q. ; Ji, S. L.; Fong, C. C.; Yang, M. S. “Cell adhesion and spreading behavior on vertically aligned silicon nanowire arrays”, ACS Applied Material Interfaces, 2009, 1(1), 30-34.

Yi, C. Q.; Liu, D. D.; Yang, M. S. “Building nanoscale architectures by directed synthesis and self-assembly”, Current Nanoscience, 2009, 54(1), 66-71.

Yi, C. Q.; Liu, D. D.; Yang, M. S. “Modulation of multilineage differentiation of mesenchymal stem cells by carboxylated carbon nanotubes”, ACS Nano, in press.

III. Molecular Medicine 1.

Zhang, Y.; Fong, C. C.; Wong, M. S.; Tzang, C. H.; Lai, W. P.; Fong, W. F.; Sui, S. F.; Yang, M. S. “Molecular mechanisms of survival and apoptosis in RAW 264.7 macrophages under oxidative stress”, Apoptosis, 2005, 10, 545-556.

Lau, S. H.; Sham, J. S. T.; Xie, D.; Tzang, C. H.; Tang, D.; Ma, N.; Hu, L.; Wang, Y.; Wen, J. M.; Xiao, G.; Zhang, W. M.; Lau, G. K. K.; Yang, M. S.; Guan, X. Y. “Clustin plays an important role in hepatocellular carcinoma metastasis”, Oncogene, 2006, 25, 1242-1250.

Shi, Y. F.; Fong, C. C.; Cheung, P. Y.; Zhang, Q.; Wu, R. S. S.; Yang, M. S. “Hypoxia induces the activation of human hepatic stellate cells LX-2 activation through TGF-? signaling pathway”, FEBS Letters, 2007, 581, 203-210.

Fong, C. C.; Zhang, Q.; Shi, Y. F.; Wu, R. S. S.; Fong, W. F.; Yang, M. S. “Effect of hypoxia on RAW264.7 macrophages apoptosis and signalling”, Toxicology, 2007, 235, 52–61.

Fong, C. C.; Zhang, Y.; Zhang, Q.; Tzang, C. H.; Fong, W. F.; Wu, R. S. S.; Yang, M. S. “Dexamethasone protects RAW264.7 macrophages from growth arrest and apoptosis induced by H2O2 through alteration of gene expression patterns and inhibition of nuclear factor-kappa B (NF-?B) activity”, Toxicology, 2007, 236, 16-28.

Wang, J.; Tai, L. S.; Tzang, C. H.; Fong W. F.; Guan, X. Y.; Yang, M. S. “1p31, 7q21 and 18q21 chromosomal aberrations and candidate genes in acquired vinblastine resistance of human cervical carcinoma KB cells”, Oncology Reports, 2008, 19 (5), 1155-1164.

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Ma, N. F.; Lau, S. H.; Hu, L.; Xie, D.; Wu, J.; Yang, J.; Wang, Y.; Wu, M. C.; Fung, J.; Bai, X. Y.; Tzang, C. H.; Fu, L.; Yang, M. S.; Su, Y. A.; Guan, X. Y. “COOH-terminal truncated HBV X protein plays key role in hepatocarcinogenesis”, Clinical Cancer Research, 2008, 14 (16), 5061-5068.

Zeng, Y.; Yang, Z.; Xu, J. G.; Yang, M. S.; Zeng, Z. X.; You, C. “Differentially expressed genes from the glioblastoma cell line SHG-44 treated with all-trans retinoic acid in vitro”, Journal of Clinical Neuroscience, 2009, 16(2), 285-294.

Wang, J.; Chan, J. Y. W.; Fong, C. C.; Tzang, C. H.; Fung, K. P.; Yang, M. S. “Transcriptional analysis of doxorubicin-induced cytotoxicityand resistance in human hepatocellular carcinoma cell lines”, Liver International, 2009, 1338-1347.

Fang, Y. J.; Deng, H. B.; Thomas, G. N.; Tzang, C. H.; Li, C.-X.; Xu, Z.-L.; Yang, M. S.; Tomlinson, B. “Linkage of angiotensinogen gene polymorphisms with hypertension in a sibling study of Hong Kong Chinese”, Journal of Hypertension, in press. (MS number: JH-D-09-00858R1)

Yip, Y. C.; Ngai, K. L. K.; Tzang, C. H.; Ji, S. L.; Yang, M. S.; Chan, P. K. S. “Prevalence and genotype distribution of cervical human papillomavirus infection in Macao”, Journal of Medical Virology, accepted.

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Ma, N. F.; Lau, S. H.; Hu, L.; Xie, D.; Wu, J.; Yang, J.; Wang, Y.; Wu, M. C.; Fung, J.; Bai, X. Y.; Tzang, C. H.; Fu, L.; Yang, M. S.; Su, Y. A.; Guan, X. Y. “COOH-terminal truncated HBV X protein plays key role in hepatocarcinogenesis”, Clinical Cancer Research, 2008, 14 (16), 5061-5068.

Zeng, Y.; Yang, Z.; Xu, J. G.; Yang, M. S.; Zeng, Z. X.; You, C. “Differentially expressed genes from the glioblastoma cell line SHG-44 treated with all-trans retinoic acid in vitro”, Journal of Clinical Neuroscience, 2009, 16(2), 285-294.

Wang, J.; Chan, J. Y. W.; Fong, C. C.; Tzang, C. H.; Fung, K. P.; Yang, M. S. “Transcriptional analysis of doxorubicin-induced cytotoxicityand resistance in human hepatocellular carcinoma cell lines”, Liver International, 2009, 1338-1347.

Fang, Y. J.; Deng, H. B.; Thomas, G. N.; Tzang, C. H.; Li, C.-X.; Xu, Z.-L.; Yang, M. S.; Tomlinson, B. “Linkage of angiotensinogen gene polymorphisms with hypertension in a sibling study of Hong Kong Chinese”, Journal of Hypertension, in press. (MS number: JH-D-09-00858R1)

Yip, Y. C.; Ngai, K. L. K.; Tzang, C. H.; Ji, S. L.; Yang, M. S.; Chan, P. K. S. “Prevalence and genotype distribution of cervical human papillomavirus infection in Macao”, Journal of Medical Virology, accepted.

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