清华大学生命科学学院上目录导师简介（44人）

清华大学生命科学学院上目录导师简介（44人）

陈国强 教授，博士生导师 ........................................................................................................................ 2 陈晔光 教授、博士生导师 .......................................................................................................................... 3 陈应华 博士 教授，长江特聘教授 .............................................................................................................. 4 高海啸 博士 教授 博士生导师 .................................................................................................................. 5 高宁 博士生导师......................................................................................................................................... 7 龚海鹏 副教授，博士生导师 .................................................................................................................... 7 李蓬 博士， 教授 清华大学生命科学学院副院长 .................................................................................... 8 刘栋 教授 ................................................................................................................................................... 9 刘进元 博士 教授 博士生导师 中国农业生物化学与分子生物学分会副理事长 ..................................... 10 刘玉乐 博士 教授，百人教授，国家杰出青年基金获得者，博士生导师 ................................................. 12 罗弘 博士 教授 博士生导师 ................................................................................................................. 13 罗永章 博士 教授，博士生导师，长江学者特聘教授，国家杰出青年基金获得者 .................................. 14 雷建林 博士 教授 博士生导师 ................................................................................................................. 15 孟安明 博士教授，博士生导师，长江特聘教授，国家杰出青年基金获得者 中科院院士 ...................... 16 潘俊敏 博士 教授，博士生导师 ............................................................................................................. 18 潘宪明 博士 教授，博士生导师，国家杰出青年基金获得者 ................................................................. 19 施一公 博士 教授，博士生导师，长江讲座教授，国家杰出青年基金获得者 ........................................ 20 隋森芳 博士 教授 博士生导师 ........................................................................................................... 21 陶庆华 博士 教授，博士生导师 ............................................................................................................. 23 王志新教授、院士，博士生导师 ............................................................................................................... 24 王新泉 博士 教授 博士生导师 ............................................................................................................ 25 吴嘉炜教授、博士生导师 .......................................................................................................................... 26 吴庆余 教授，博士生导师，国家杰出青年基金获得者，首届国家教学名师奖获得者 ............................. 27 吴 畏 教授, 博士生导师 ......................................................................................................................... 28 谢道昕 博士 教授，博士生导师，教育部长江学者特聘教授，国家杰出青年基金获得者 ....................... 29 闫永彬 博士，副研究员，博士生导师 ...................................................................................................... 31 俞立 博士 教授 博士生导师 .............................................................................................................. 32 杨茂君 博士 教授 博士生导师 ......................................................................................................... 33 张大鹏 博士 教授 博士生导师 .......................................................................................................... 34 张荣庆 博士 教 授 博士生导师 ...................................................................................................... 35 周 兵 博士 教授 博士生导师 国家杰出青年基金获得者 ..................................................................... 36 程京 教授，博士生导师 ............................................................................................................................ 38 王钊 博士，药理学与毒理学教授，博士生导师 ....................................................................................... 40 张林琦 教授、博士生导师、长江特聘教授、国家杰出青年基金获得者 ................................................. 41 祁海 博士，特别研究员 ........................................................................................................................... 42 刘国松 教授，博士生导师 ...................................................................................................................... 44 孙方霖 教授，博士生导师，长江学者特聘教授，国家杰出青年科学基金获得者 .................................. 45 常智杰 教授，博士生导师 ........................................................................................................................ 46 杜力军 博士，教授，博士生导师 ........................................................................................................... 47 邢婉丽 研究员，博士生导师 .................................................................................................................... 48 颜宁 教授、博士生导师 ........................................................................................................................ 49 吴励 教授， 博士生导师 .......................................................................................................................... 50 李海涛 博士，特别研究员 .................................................................................................................... 51

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张敬仁 博士，特别研究员 .................................................................................................................... 53

陈国强 教授，博士生导师

教育工作经历

广州华南理工大学 学士，1981-1985

奥地利格拉茨工业大学 博士，1986-1989 英国诺丁汉大学，博士后，1990-1992 加拿大阿尔伯达大学，博士后，1992-1994 清华大学，副教授，1994-1997 清华大学，教授，1997-今 研究领域及方向

工业生物技术和合成生物学

微生物合成高分子材料聚羟基脂肪酸酯(PHA) 微生物代谢工程及微生物合成生物学 PHA在微生物中生理作用的研究 PHA作为组织工程材料的应用研究?

PHA作为可降解材料和生物燃料的应用研究?

共在国际学术期刊上发表文章140多篇，近年代表作如下:

1. Chen GQ. A Polyhydroxyalkanoates Based Bio- and Materials Industry. Chem Soc Rev 2009,

DOI:10.1039/b812677c

2. Zhang XJ, Luo RC, Wang Z, Deng Y and Chen GQ. Applications of (R)-3-hydroxyalkanoate

Methyl Esters Derived from Microbial Polyhydroxyalkanoates as Novel Biofuel. Biomacromolecules 10 (2009) 707–711

3. Cai L, Yuan MQ, Liu F, Jian J and Chen GQ. Enhanced Production of Polyhydroxyalkanoates

by PHA depolymerase knockout mutant of Pseudomonas putida KT2442. Bioresource Technol. 100 (2009) 2265-2270

4. Zou XH, Li HM, Wang S, Leski M, Yao YC, Yang XD, Huang QJ and Chen GQ. The Effect of

3-Hydroxybutyrate Methyl Ester on Learning and Memory in Mice. Biomaterials 30 (2009) 1532–1541

5. Shen XW, Yang Y, Jian J, Wu Q and Chen GQ. Production and Characterization of Homopolymer

poly(3-hydroxyvalerate) (PHV) Accumulated by Wild type and Recombinant Aeromonas hydrophila Strain 4AK4. Bioresource Technol 100 (2009) 4296–4299

6. Chung A, Liu Q, Ouyang SP, Wu Q and Chen GQ. Microbial production of 3-hydroxydodecanoic

acid by pha-operon and fadBA knockout mutant of Pseudomonas putida KT2442 harboring tesB gene. Appl Microbiol Biotechnol 83 (2009) 513 – 519

7. Wang ZH, Wu HN, Chen J, Zhang J and Chen GQ. A novel self-cleaving phasin tag for

purification of recombinant proteins based on hydrophobic nanoparticles. Lab on a Chip 8 (2008) 1957-62

8. Chen GQ, Wu Q. Microbial Production and Applications of Chiral Hydroxyalkanoates. Appl

Microbiol Biotechnol 67 (2005) 592 – 599

9. Chen GQ and Wu Q. Polyhydroxyalkanoates as Tissue Engineering Materials. Biomaterials

26 (2005) 6565–6578

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10. Zheng Z, Gong Q, Liu T, Deng Y, Chen JC and Chen GQ. Thioesterase II of Escherichia coli

plays an important role in 3-hydroxydecanoic acid production. Appl Environ Microbiol 70 (2004): 3807-3813

联系方式：

清华大学生命科学学院微生物实验室，北京100084 电话：+86-10-62783844；传真：+86-10-62794217 E-mail: chengq@mail.tsinghua.edu.cn

陈晔光 教授、博士生导师

教育工作经历:

1979-1983，就读于江西大学生物系，获生物学学士学位。 1983-1986，就读于江西大学生物系，获动物学硕士学位。

1988-1990，就读于Fordham University，获细胞生物学硕士学位。

1991-1996，就读于美国Albert Einstein College of Medicine，获Ph.D.学位

1996-2000, Post-doctoral Research Associate, Memorial Sloan-Kettering Cancer Center/Howard Hughes Medical Institute.

2000-2002, Assistant Professor, University of California, Riverside. 2002-至今，清华大学教授。

研究兴趣、领域

细胞信号转导：利用膜生物学、分子生物学、生物化学、细胞生物学和发育生物学等多学科技术手段研究TGF-β和Wnt信号的调控以及它们在器官发育、干细胞自我更新和分化、肿瘤形成中的作用。 开设的课程:《细胞生物学》、《细胞信号转导与疾病的发生》、《肿瘤生物学专题讨论》

代表性论文：

1. Zuo W, Chen YG# 2009 Specific activation of MAPK by TGF-β receptors in lipid rafts is

required for epithelial cell plasticity. Molecular Biology of the Cell, 20:1020-1029. 2. Gao X, Wen J, Zhang L, Li X, Ning Y, Meng A, Chen YG#. 2008 Dapper1 is a nucleocytoplasmic

shuttling protein that negatively modulates Wnt signaling in the nucleus. Journal of Biological Chemistry, 283:35679-35688.

3. Zhao X, Nicholls JM, Chen YG# 2008 SARS-CoV nucleocapsid protein interacts with Smad3 and

modulates TGF-β signaling. Journal of Biological Chemistry, 283:3272-3280.

4. Wang Q, Huang Z, Xue H, Jin C, Ju XL, Han JD, Chen YG# 2008 MicroRNA miR-24 inhibits

erythropoiesis by targeting activin type I receptor ALK4. Blood, 111:588-595.

5. Lin Z, Gao C, Ning Y, He X, Wu W, Chen YG# 2008 The pseudoreceptor BMP and activin

membrane-bound inhibitor positively modulates Wnt/β-catenin signaling. Journal of Biological Chemistry, 283:33053-33058.

6. Ma J, Wang Q, Fei T, Han JD, Chen YG# 2007 MCP-1 mediates TGF-β-induced angiogenesis by

stimulating vascular smooth muscle cell migration. Blood, 109:987-994.

7. Zhang S, Fei T, Zhang L, Zhang R, Chen F, Ning Y, Han Y, Feng XH, Meng A, Chen YG# 2007

Smad7 antagonizes TGF-β signaling in the nucleus by interfering with functional Smad-DNA complex formation. Molecular and Cellular Biology, 27:4488-4499.

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8. Chen YG#, Wang Z, Ma J, Zhang L, Lu Z 2007 Endofin, a FYVE domain protein, interacts with

Smad4 and facilitates TGF-β signaling. Journal of Biological Chemistry, 282:9688-9695. 9. Gu Y, Jin P, Zhang L, Zhao X, Gao X, Ning Y, Meng A, Chen YG# 2006 Functional analysis

of mutations in the kinase domain of the TGF-β receptor ALK1 reveals different mechanisms for induction of hereditary hemorrhagic telangiectasia. Blood, 107:1951-1954. 10. Zhang L, Gao X, Wen J, Ning Y, Chen YG# 2006 Dapper 1 antagonizes Wnt signaling by promoting

Dishevelled degradation. Journal of Biological Chemistry, 381:8607–8612.

11. Zhang, L., Zhou, H., Su, Y., Sun, S., Zhang, H., Zhang, L., Zhang, Y., Ning, Y., Chen,

YG# and Meng, A# 2004 Zebrafish Dpr2 inhibits mesoderm induction by promoting degradation of Nodal receptors. Science, 306:114-117

12. Lu, Z., Murray, J. T., Luo, W., Li, H., Wu, X., Xu, H., Backer, J. M. and Chen, Y.G# 2002

Transforming growth factor-β activates Smad2 in the absence of receptor endocytosis. Journal of Biological Chemistry, 277:29363-29368.

13. Wu G*, Chen YG*, Ozdamar B, Gyuricza C, Chong PA, Wrana JL, Massagué J, Shi Y. 2000

Structural basis of Smad2 recognition by the Smad Anchor for Receptor Activation. Science. 287:92-97.

14. Onichtchouk, D*, Chen, YG*, Dosch, R., Gawantka, V., Delius, H., Massagué, J. and Nierhs,

C. 1999 Silencing of TGF-β signaling by the pseudoreceptor BAMBI. Nature, 401:480-485.

荣誉、奖励及参加学术团体的情况 2008年何梁何利科学与技术进步奖

2008年清华大学生物科学与技术系“东胜创新成就奖” 2007年“新世纪百千万人才工程” 2006年中国青年科技奖

2004年教育部“中国高等学校十大科技进展” 2002-2003年度美国“李氏基金杰出成就奖” 2002年国家“杰出青年基金”获得者

2002年教育部“长江学者奖励计划”特聘教授

联系方式:

北京市清华大学生命科学学院，分子细胞学实验室 100084 电 话：010-62784794; 传 真：010-62794376 E-mail：ygchen@mail.tsinghua.edu.cn

陈应华 博士 教授，长江特聘教授

国家杰出青年基金获得者，香港求是科技基金会‘杰出青年学者奖’获得者

教育工作经历

1977－1982 武汉大学 学士（病毒学）

1983－1989 德国慕尼黑大学 博士（免疫学） 1990－1991 德国慕尼黑大学免疫学研究所 工作

1991－1996 奥地利因斯布鲁克大学 正式工作职位（课题组长） 1996－至今 回国工作 清华大学教授

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主要科研领域与方向：

艾滋病病毒基础研究；病毒表位疫苗作用机理研究；重组表位疫苗的设计与应用基础研究

代表性论文

1. Lu L, Zhu Y, Huang JH, Chen X, Yang HW, Jiang SB, Chen YH. Surface exposure of the HIV-1

Env cytoplasmic tail LLP2 domain during the membrane fusion process - Interaction with gp41 fusion core. Journal of Biological Chemistry.2008, 283(24):16723-16731.

2. Huang JH, Qi Z, Wu F, Kotula L, Jiang SB, Chen YH. Interaction of HIV-1 gp41 core with

NPF motif in Epsin - Implication in endocytosis of HIV. Journal of Biological Chemistry. 2008, 283(22):14994-15002.

3. Li J, Chen X, Jiang SB, Chen YH. Deletion of fusion peptide or mutation-induced disruption

of the HIV-1 gp41 core structure resulting in increased antigenicity and immunogenicity of 4E10 epitope. Biochemical and Biophysical Research Communications 2008,376: 60-64. 4. Lu L, Zhu Y, Diao JC, Wang ZG, Chen YH. V3CTL epitope density in a single recombinant

molecule antigen differentially affects the number and activity of primary and memory CD8(+) T cells. Vaccine.2008, 28(6):845-852. 5. Huang JH, Lu L, Lu H, Chen X, Jiang S, Chen YH. Identification of the HIV-1 gp41 core-binding

motif in the scaffolding domain of caveolin-1. Journal of Biological Chemistry. 2007, 282: 6143–6152.

6. Huang JH, Yang HW, Liu S, Jiang S, Chen YH. The mechanism by which molecules containing

the HIV-1 gp41 core-binding motif HXXNPF inhibit HIV-1 envelope glycoprotein-mediated syncytium-formation. Biochemical Journal.2007, 403: 565-571

7. J.H. Huang, Z.Q. Liu, S. Liu, S.Jiang, Y.H. Chen. Identification of the HIV-1 gp41

core-binding motif-HXXNPF. FEBS Letters. 2006, 580:4807-4814

8. Wanli Liu, Ying-Hua Chen. High epitope density in single protein molecule significantly

enhanced antigenicity as well as immunogenicity: a novel strategy for modern vaccine development and a preliminary investigation about B cell discrimination of monomeric proteins. European Journal of Immunology. 2005, 35:505-14.

9. Wanli Liu, Peng Zou, Jian Ding, Yun Lu, Ying-Hua Chen. Sequence comparison of the

extracellular domain of M2 protein between human and avian influenza a virus provides new information for bivalent influenza vaccine design. Microbes Infect. 2005, 7:171-177 10. Dong XN, Chen X, Chen Y, Ablimit A, Ye Z, Wu Y, Ying-Hua Chen. Short Communication: HIV

Type 1 Phenotype, Tropism, and Sequence Patterns: Association and Preference. AIDS Res Hum Retroviruses. 2005, 21:234-8

联系方式:

电话：+86-10-62789385 传真：+86-10-62771613

E-mail:chenyh@tsinghua.edu.cn

高海啸 博士 教授 博士生导师

教育工作经历

1993年，兰州大学物理系理论物理专业 学士 1996年，北京工业大学物理系理论物理专业 硕士

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4. Weidner, E., Frey, F., Lei, J., Pedersen, B., Paulmann, C., and Morgenroth, W. (2004).

Disordered quasicrystals: diffuse scattering in decagonal Al-Ni-Fe. J. Appl. Cryst. 37, 802-807

5. Weidner, E., Lei, J., Frey, F., Wang, R., and Grushko, B. (2002). Diffuse scattering in

decagonal Al–Ni–Fe. Journal of Alloys and Compounds 342, 156-158. 6. Lei, J., Wang, R., Yin, J., and Duan, X. (2002). Diffuse electron scattering determination

of elastic constants of Al–Pd–Mn icosahedral quasicrystal. Journal of Alloys and Compounds 342, 326-329.

7. Wang, R., Hu, C., Lei, J. (2001). Theory of diffuse scattering of quasicrystals due to

fluctuations of thermalised phonons and phasons. Phys. Stat. Sol. (b) 225, 21-34. 8. Lei, J., Wang, R., Hu, C., and Ding, D. (2000). Diffuse scattering from dodecagonal

quasicrystals. Eur. Phys. J. B 13, 21-30.

9. Wang, R., Hu, C., Lei, J., and Ding, D. (2000). Theoretical aspects of thermal diffuse

scattering from quasicrystals. Phys. Rev. B 61, 5843-5845.

10. Lei, J., Wang, R., Hu, C., and Ding, D., (1999). Diffuse scattering from decagonal

quasicrystals. Phys. Rev. B 59, 822-828.

11. Lei, J., Hu, C., Wang, R., and Ding, D., (1999). Diffuse scattering from octagonal

quasicrystals. J. Phys.: Condens. Matter 11, 1211-1223.

12. Lei, J., Wang, R., Hu, C., and Ding, D. (1998). Diffuse scattering from pentagonal

quasicrystals. Phys. Lett. A 247, 343-352.

13. Wang, J., Lei, J., and Wang, R. (1998). Diffraction pattern calculation and phase

identification of hypothetical crystalline C3N4. Phys. Rev. B 58, 11890-11895.

联系方式

电话: +86-10-62797699 传真: +86-10-62784259

E-mail: jllei@tsinghua.edu.cn

孟安明 博士教授，博士生导师，长江特聘教授，国家杰出青年基金获得者 中科院院士

教育工作经历

1979－1983，西南农业大学 学士 1987－1990，英国诺丁汉大学 博士

1990－1996，中国农业大学博士后、副教授 1996－1998，美国佐治亚医学院访问学者 1998至今，清华大学教授

主要科研领域与方向：

脊椎动物胚胎的分子发育生物学。主要利用斑马鱼做模式动物，分离克隆Nodal和FGF等信号通路的新的介导因子和调节因子，结合分子生物学、细胞生物学、遗传学等技术，研究它们在胚胎发育中的作用及其作用机制。利用诱变技术，鉴定影响早期胚胎发育的母源因子。

学术荣誉与奖励：

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2008年当选发展中国家科学院（原第三世界科学院）院士；2007年当选中国科学院院士；2007年获得何梁何利基金科学与技术进步奖；2006年入选国家“新世纪百千万人才工程国家级人选”；2002年被评为教育部“全国高等学校优秀骨干教师”；2001年入选第四批教育部长江学者计划特聘教授；2000年入选教育部第二届“高校优秀青年教师教学科研奖励计划”；2000年入选教育部跨世纪优秀人才培养计划；2000年获得国家杰出青年基金；2000年获得香港求是科学技术基金会“杰出青年学者”奖(生物医学)；1999年入选清华大学“百名人才引进计划”；1991年获第三届霍英东青年教师基金奖。

现任第15届中国动物学会副理事长，中国细胞生物学会理士，Asia Pacific Developmental Biology Network (APDBN)组委会成员，Current Zoology主编，BMC Developmental Biology副主编，Journal of Cell Science、Journal of Biological Chemistry、Cell Research等杂志编委会成员；科技部“发育与生殖研究”重大科学研究计划专家组成员。

代表性论文

1. Zhang Y, Li X, Qi JJ, Wang J, Liu X, Zhang H, Lin SC, Meng AM. 2009. Rock2 controls TGF-beta

signaling and inhibits mesoderm induction in zebrafish embryos. Journal of Cell Science, 122:2197-207.

2. Jia SJ, Wu D, Xing CC, Meng AM. 2009. Smad2/3 activities are required for induction and

patterning of the neuroectoderm in zebrafish.Developmental Biology, 333:273-284. 3. Zhao L, Zhao XY, Tian T, Lu QL, Skrbo-Larssen N, Wu D, Kuang Z, Zheng XF, Han YC, Yang

SY, Zhang CM, Meng AM. 2008. Heart-specific isoform of tropomyosin4 is essential for heartbeat in zebrafish embryos. Cardiovascular Research, 80(2):200-208.

4. Meng FW, Cheng X, Yang LL, Hou N, Yang X, Meng AM. 2008. Accelerated re-epithelialization

in Dpr2-deficient mice is associated with enhanced response signaling. Journal of Cell Science, 121(17):2904-2912.?to TGF-beta

5. Jia SJ, Ren Z, Li X, Zheng Y, Meng AM. 2008. smad2 and smad3 are required for mesendoderm

induction by TGF-beta/Nodal signals in zebrafish. Journal of Biological Chemistry, 283(4):2418-2426.

6. Huang HZ, Lu F-I, Jia SJ, Meng S, Cao Y, Wang YQ, Ma WP, Yin K, Wen ZL, Peng JR, Thisse

C, Thisse B, Meng AM. 2007. Amotl2 is essential for cell movements in zebrafish embryo and regulates c-Src translocation. Development, 134(5): 979-988.

7. Su Y, Zhang L, Gao X, Meng FW, Wen J, Zhou H, Meng AM, Chen YG. 2007. The evolutionally

conserved activity of Dapper2 in antagonizing TGFbeta signaling. The FASEB Journal, 21(3):682-90.

8. Rui RY, Xu Z, Xiong B, Cao Y, Lin SY, Zhang M, Chan SC, Luo W, Han Y, Lu ZL, Ye ZY, Zhou

HM, Han JH, Meng AM, Sheng-Cai Lin. 2007. Abeta -catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by Aida. Developmental Cell, 13(2):268-282.

9. Xiong B, Rui YN, Zhang M, Shi KH, Jia SJ, Tian T, Yin K, Huang HZ, Lin SY, Zhao XG, Chen

YH, Chen Y-G, Lin S-C, Meng AM. 2006. Tob1 controls dorsal development of zebrafish embryos by antagonizing maternalbeta-Catenin transcriptional activity. Developmental Cell, 11:225-238.

10. Lin X, Duan XY, Liang Y-Y, Su Y, Wrighton KH, Long JY, Hu M, Davis CM, Wang JR, Brunicardi

FCB, Shi YG, Chen Y-G, Meng AM, Feng X-H. 2006. PPM1A functions as a Smad phosphatase to terminate TGF-beta signaling. Cell, 125(5):915-928.

11. Zhang L, Zhou H, Su Y, Sun Z, Zhang H, Zhang L, Zhang Y, Ning Y, Chen Y-G, Meng AM. 2004.

Zebrafish Dpr2 inhibits mesoderm induction by promoting lysosomal degradation of Nodal receptors. Science, 306(5693):114-117.

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12. Cao Y, Zhao J, Sun ZH, Postlethwait J, Meng AM. 2004. fgf17b, a novel member of Fgf family,

helps patterning zebrafish embryos. Developmental Biology, 271(1):130-143.

13. Penberthy WT, Zhao CT, Zhang Y, Jessen JR, Yang Z, Bricaud O, Collazo A, Meng A, Lin S.

2004. Pur alpha and Sp8 as opposing regulators of neural gata2 expression. Developmental Biology, 275(1):225-234.

14. Zhao J, Cao Y, Zhao CT, Postlethwait J, Meng AM. 2003. An SP1-like transcription factor

Spr2 acts downstream of Fgf signaling to mediate mesoderm induction. EMBO Journal, 22(22): 6078-6088. 15. Zhao ZX, Cao Y, Li M, Meng AM. 2001. Injection of double-stranded RNA produces nonspecific

defects in zebrafish. Developmental Biology, 229(1):215-223.

16. Zhang LX, Hua ZC, Ren JG, Meng A. 2001. The nuclear localization signal of zebrafish terra

is located within the DM domain. FEBS Letters, 503(1):25-29.

17. Meng AM, Moore B, Tang H, Yuan BZ and Lin S. 1999. Drosophila doublesex-related gene,

terra, is involved in somitogenesis in vertebrates. Development, 126:1259-1268. 18. Meng A, Tang H, Yuan BZ, Ong BA, Long Q, Lin S. 1999. Positive and negative cis-acting

elements are required for hematopoietic expression of zebrafish GATA-1. Blood, 93(2):500-508.

19. Meng A, Jessen J, Lin S. 1999. Transgenesis. Methods in Cell Biology, 60: 133-148. 20. Jessen JR, Meng AM, Paw BH, Zon LI, Lin S. 1998. Modification of bacterial artificial

chromosomes through chi-stimulated homologous recombination and its application in zebrafish transgenesis. Proc. Natl. Acad. Sci. USA, 95:5121-5126.

21. Meng AM, Tang H, Ong BA, Farrell MJ, Lin S. 1997. Promoter analysis in living zebrafish

embryos identifies a cis-acting motif required for neuronal expression of GATA-2. Proc. Natl. Acad. Sci. USA, 94:6267-6272.

22. Long QM, Meng AM, Wang H, Jessen JR, Farrell MJ, Lin S. 1997. GATA-1 expression pattern

can be recapitulated in living transgenic zebrafish using GFP reporter gene. Development, 124:4105-4111.

联系方式:

电话：+86-10-62772256 传真：+86-10-62794401

E-mail:mengam@mail.tsinghua.edu.cn

潘俊敏 博士 教授，博士生导师

教育工作经历：

河北师范大学学士， 1986 中国科学院水生所硕士，1989 德国弗赖堡大学博士，1996

美国西南医学中心，博士后，1999 美国西南医学中心，Instructor，2001

美国西南医学中心，Research Assistant Prof., 2006 清华大学, 教授, 博士生导师，2006

研究兴趣、领域：

18

信号传导与细胞骨架：纤毛或真核生物的鞭毛是基于细胞微管的一种亚细胞结构。它不仅起着细胞运动的作用，它还参与动物的发育、细胞分裂和维持各种器官的正常生理功能。纤毛的缺陷会导致多种疾病诸如呼吸道疾病、肾囊肿，内脏转位，肥胖症等。我们利用模式生物衣藻为材料，采用分子生物学、生物化学、细胞生物学等手段，研究纤毛的形成、解聚机理，运动功能、信号传导及在细胞分裂中的调控作用。由于纤毛的高度保守性，我们的研究成果适用于动物细胞的纤毛。我们的发现将对纤毛相关疾病的发病机理的认识、诊断和治疗提供理论上的支撑。

微藻技术的开发和利用：进行微藻的培养，转基因技术和生物活性物质、生物再生能源的研究。

代表性论文 （2004年后）：

1. Piao tian, , Minna Luo, Liang Wang, Yan Guo，De Li, Peng Li, William J. Snell， Junmin

Pan*. 2009. A microtubule depolymerizing kinesin functions during both flagellar disassembly and flagellar assembly in Chlamydomonas. PNAS, 106, 4713-4718 (direct submission).

2. Cao Muqing, Yu Fu, Yan Guo and Junmin Pan*. 2009. Chlamydomonas (Chlorophyceae) colony

PCR. Protoplasma, 235, 107.

3. Junmin Pan*. 2008. Cilia and ciliopathies: From Chlamydomonas and beyond. Sci China Ser

C-Life Sci, 51, 479-486.

4. Junmin Pan and William Snell. 2007. The primary cilum: Keeper of the key to cell division.

Cell, 129, 1255-1257.

5. Merchant S., ?, Junmin Pan, et al., 2007. The Chlamydomonas Genome Reveals the Evolution

of Key Animal and Plant Functions. Science, 318, 245-250.

6. Wang Q. Junmin Pan, and William Snell. 2006. A new role for intraflagellar transport:

Intraflagellar transport particles participate directly in signal transduction during cilium-generated signaling in Chlamydomonas. Cell, 125, 549-562

7. Junmin Pan and William Snell. 2005. Chlamydomonas shortens its flagella by activating

disassembly, stimulating IFT particles and blocking anterograde cargo loading. Developmental Cell, 9, 431-438. 8. Junmin Pan, Q. Wang, and William Snell. 2005. Cilium-generated signaling and cilia-related

disorders. Laboratory Investigation, 85, 452-463.

9. Junmin Pan, Qian Wang and William J. Snell. 2004. An Aurora Kinase Is Essential for

Flagellar Disassembly in Chlamydomonas. Developmental Cell, 6: 445-451.

10. William J. Snell, Junmin Pan and Qian Wang. 2004. Cilia and flagella revealed: from

flagellar assembly in Chlamydomonas to Human obesity disorders. Cell, 117, 693-697.

联系方式：

清华大学生命科学学院 100084 电话/传真：010-62771864

E-mail：panjunmin@tsinghua.edu.cn

潘宪明 博士 教授，博士生导师，国家杰出青年基金获得者

教育工作经历

1978-1981年,复旦大学 学士 1982-1984年,北京大学 硕士

1986-1989年,德国Bochum大学 博士

19

现任清华大学教授

主要科研领域与方向：生物化学,蛋白质折叠和蛋白质结构预测。

代表性论文

1. Sheng X. R., Zhang H. J., Pan X. M. and Zhou J.M. (1997) Domain movement in rabbit muscle

adenylate kinase might involve proline isomerization. FEBS Letters, 413, 429-432. 2. Zhang H. J., Sheng X. R., Pan X. M.* and Zhou J.M. (1997) Activation of adenylate kinase

by denaturatants is due to the increasing flexibility at its active sites. BBRC, 238, 382-386. 3. Zhang H. J., Sheng X. R., Niu W. D., Pan X. M.* and Zhou J.M. (1998) Rabbit Muscle Adenylate

Kinase: Evidence for at Least Two Native forms in Equilibrium in Aqueous Solution. J. Biol. Chem., 273, 7448-7456.

4. Zhang H. J., Sheng X. R., Pan X. M.* and Zhou J. M. (1998) Refolding of urea-denatured

adenylate kinase. Biochem. J., 333, 401-405. 5. Sheng X. R., Li X. and Pan X. M.* (1999) An Iso-random Bi Bi mechanism for adenylate kinase.

J. Biol. Chem., 274, 22238-22243.

6. Li X. and Pan X. M.* (2001) New Method for accurate prediction of solvent accessibility

from protein sequence. Proteins, structure, Function, and Genetics, 42, 1-5.

7. Pan X. M.* (2001) Multiple linear regression for protein secondary structure prediction.

Proteins, structure, Function, and Genetics. 43, 256-9

8. Li X., Yang Han and Pan X. M.*(2001) Cysteine-25 of adenylate kinase reacts with

dithiothreitol to form an adduct upon aging of the enzyme. FEBS Letters, 507 (2) 169-173. 9. Han Y. , Li X. and Pan X. M.*(2002) Native States of adenylate kinase are two active

sub-ensembles. FEBS Letter, 528 161-165

10. Xu S., Qin S. and Pan X. M.* (2004)Thermal and Conformational Stability of Ssh10b Protein

from Archaeon Sulfolobus shibattae. Biochem. J, 382, 433-440.

联系方式:

电话：+86-10-62792827 传真：+86-10-62792827

E-mail:pan-xm@mail.tsinghua.edu.cn

施一公 博士 教授，博士生导师，长江讲座教授，国家杰出青年基金获得者

教育工作经历

1985-1989 清华大学生物科学与技术系，学士

1990-1995 美国约翰霍普金斯大学医学院，分子生物物理学博士 1995 美国约翰霍普金斯大学医学院，博士后

1996-1997 美国史隆凯特林癌症研究中心结构生物学实验室，博士后 1998-2001 美国普林斯顿大学分子生物学系，助理教授

2001-2003 美国普林斯顿大学分子生物学系，（终身）副教授 2003-2008 美国普林斯顿大学分子生物学系，（终身）教授

2007-2008 美国普林斯顿大学分子生物学系，Warner-Lambert/Parke-Davis教授 2008-至今 清华大学生命科学学院，教授、博士生导师

20

2. Wang XQ, Baloh RH, Milbrandt J and Garcia KC. Structure of Artemin with its receptor GFRa3:

3. 4.

5.

6.

convergent recognition of glial-cell line derived neurotrophic factors. Structure 14,

1083-1092 (2006).

Wang XQ*, Rickert M* and Garcia KC. Structure of the quaternary complex of interleukin-2 with of its a, b, and gc receptors. Science 310, 1159-1163 (2005). *equal authorship. Rickert M*, Wang XQ*, Boulanger MJ, Goriatcheva N and Garcia KC. The structure of Interleukin-2 complexed with its alpha receptor. Science 308, 1477-1480 (2005). *equal authorship.

Wang XQ, He XY, Yang SJ, An XM, Chang WR and Liang DC. Structural basis for the thermostability of b-glycosidase from the thermophilic eubacterium Thermus nonproteolytics HG102. J. Bacteriol. 185, 4248-4255 (2003). Wang XQ, Li LN, Chang WR, Zhang JP, Gui LL, Guo, BJ and Liang DC. Structure of C-phycocyanin from Spirulina platensis at 2.2A resolution: a novel monoclinic crystal form for phycobiliproteins in phycobilisomes. Acta Cryst. D57, 784-792 (2001).

联系方式:

电话：+86-10-62789401 传真：+86-10-62792736

E-mail: xinquanwang@mail.tsinghua.edu.cn

吴嘉炜教授、博士生导师

教育工作经历：

1990-1994，南京大学基础学科教育强化部，获生物化学学士学位 1994-1999，中国科学院生物物理研究所，获分子生物学博士学位 1999-2003，普林斯顿大学分子生物学系，博士后，研究助理 2003- 清华大学生命科学学院，教授

研究方向：

生物大分子的结构生物化学研究：

糖尿病、肥胖症等疾病中关键蛋白的结构和功能研究 Wnt信号转导中骨架蛋白Axin及其相互作用蛋白的研究 MAPK信号通路中激酶和磷酸酶活力调控的分子机制 TGF-b信号通路中Smad蛋白的泛素化降解机制

代表性论文：

1. Chen L, Jiao ZH, Zheng LS, Zhang YY, Xie ST, Wang ZX, Wu JW*. (2009) Structural insight

into the autoinhibition mechanism of AMP-activated protein kinase. Nature. [Epub ahead of print]

2. Zhang YY, Mei ZQ, Wu JW*, Wang ZX*. (2008) Enzymatic activity and substrate specificity

of mitogen-activated protein kinase p38alpha in different phosphorylation states. J Biol Chem. 283(39):26591-601.

3. Wang ZX*, Wu JW.* (2007) The complete pathway for ERK2-catalyzed reaction. Evidence for

an iso random Bi-Bi mechanism. J Biol Chem. 282(38): 27678-84.

26

4. Yan N, Wu JW, Chai J, Li W, Shi Y. (2004) Molecular mechanisms of DrICE inhibition by DIAP1

and removal of inhibition by Reaper, Hid and Grim. Nat Struct Mol Biol. 11(5):420-8. 5. Chai J, Wu JW, Yan N, Massague J, Pavletich NP, Shi Y. (2003) Features of a Smad3 MH1-DNA

complex. Roles of water and zinc in DNA binding. J Biol Chem. 278(22):20327-31.

6. Wu WJ, Krawitz AR, Chai J, Li W, Luo K, Shi Y. (2002) Structural mechanism of Smad4

recognition by the nuclear oncoprotein Ski: insights on Ski-mediated repression of TGF-beta signaling. Cell. 111(3): 357-367. 7. Wu JW, Hu M, Chai J, Seoane J, Huse M, Li C, Rigotti DJ, Kyin S, Muir TW, Fairman R, Massague

J, Shi Y. (2001) Crystal structure of a phosphorylated Smad2. Recognition of phosphoserine by the MH2 domain and on Smad function in TGF-beta signaling. Mol Cell. 8(6),1277-89. (Cover story)

8. Wu JW, Cocina AE, Chai J, Hay BA, Shi Y. (2001) Structural analysis of a functional DIAP1

fragment bound to grim and hid peptides. Mol Cell. 8(1), 95-104.

9. Wu JW, Wang ZX. (1999) New Evidence for the Denaturant Binding Model, Protein Sci. 8(10),

2090-2097.

10. Wu JW, Wang ZX. (1998) Activation Mechanism and Modification Kinetics of Chinese Hamster

Dihydrofolate Reductase by p-Chloromercuribenzoate, Biochem. J. 335(1), 181-189.

学术荣誉：

1997年，中国科学院院长奖优秀奖 1998年，中国科学院地奥奖

1999年，中国科学院院长奖特别奖 2001年，全国百篇优秀博士学位论文

主要学术兼职:

中国生物化学与分子生物学学会，会员

中国生物化学与分子生物学学会酶学专业委员会，委员（2007-） 中国晶体学会，会员

联系方式：

电话：010-62789387 传真：010-62792826

电子邮箱：jiaweiwu@mail.tsinghua.edu.cn 通讯地址：清华大学生命科学学院，北京 100084

吴庆余 教授，博士生导师，国家杰出青年基金获得者，首届国家教学名师奖获得者

教育工作经历

1982年，南京大学 学士 1985年，南京大学 硕士

1988年－1990年，美国William Paterson University of New Jersey 访问学者 1993年－1994年，美国Arizona State University访问学者

现任清华大学教授、生物学学位分委员会主席、生物技术研究所所长

主要科研领域与方向：微藻生物能源、蓝细菌分子生物学、微生物地球化学

27

代表性论文

1. Xiaoling Miao, Qingyu Wu, 2006, Biodiesel production from heterotrophic microalgal oil.

Bioresource Technology, 97: 841-846.

2. Han Xu and Qingyu Wu, 2006, High quality biodiesel production from a microalgae Chlorella

protothecoides by heterotrophic growth in fermenters. Journal of Biotechnology, 126: 499-507.

3. Xiufeng Li, Han Xu, Qingyu Wu, 2007, Large-scale biodiesel production from microalga

Chlorella protothecoids through heterotrophic cultivation in bioreactors. Biotechnology and Bioengineering, 98(4):764-771.

4. Wei Xiong, Qingyu Wu, 2008, High-density fermentation of microalga Chlorella

protothecoides in bioreactor for microbio-diesel production. Appl Microbiol Biotechnol, (2008) 78: 29-36.

5. Chunfang Gao, Wei Xiong, Yiliang Zhang, Wenqiao Yuan, Qingyu Wu, 2008, Rapid quantitation

of lipid in microalgae by time-domain NMR in alga-based biodiesel production, Journal of Microbiological Methods, 75 (2008) 437-440 6. Yun Cheng,Wenguang Zhou, Chunfang Gao, Kenneth Lan, Yang Gao and QingyuWu (2009), Biodiesel

production from Jerusalem artichoke (Helianthus Tuberosus L.) tuber by heterotrophic microalgae Chlorella protothecoides, J Chem Technol Biotechnol (2009), Published online in Wiley Interscience, (www.interscience.wiley.com) DOI 10.1002/jctb.2111

联系方式:

电话：+86-10-62781825 传真：+86-10-62781825

E-mail:qingyu@tsinghua.edu.cn

吴 畏 教授, 博士生导师

教育工作经历

1987-1991，四川大学，获学士学位 1991-1994，四川大学，获硕士学位

1994-1996，中国科学院微生物研究所，实习研究员 1996-2001，德国海德堡大学，获博士学位 2001-2005, 德国癌症研究中心，博士后 2005-现在, 清华大学教授

主要科研领域与方向

以非洲爪蟾、涡虫以及培养细胞为系统, 研究Wnt信号在动物胚胎发育、再生以及肿瘤发生中的功能和调控机制。

代表性论文

1. Kazanskaya O, Ohkawara B, Heroult M, Wu W, Maltry N, Augustin HG, Niehrs C.The Wnt signaling

regulator R-spondin 3 promotes angioblast and vascular development. Development. 2008 Nov;135(22):3655-64.

28

2. Lin Z, Gao C, Ning Y, He X, Wu W, Chen YG.The pseudoreceptor BMP and activin membrane-bound

inhibitor positively modulates Wnt/beta-catenin signaling.J Biol Chem. 2008 Nov 28;283(48):33053-8.

3. Barreto G, Sch?fer A, Marhold J, Stach D, Swaminathan SK, Handa V, D?derlein G, Maltry

N, Wu W, Lyko F, Niehrs C. Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation. Nature. 2007 Feb 8;445(7128):671-5.

4. *Davidson G, *Wu W, Shen J, Bilic J, Fenger U, Stannek P, Glinka A, Niehrs C. Casein kinase

1 gamma couples Wnt receptor activation to cytoplasmic signal transduction. Nature. 2005 Dec 8;438(7069):867-72. (*equal contribution) 5. Kazanskaya O, Glinka A, del Barco Barrantes I, Stannek P, Niehrs C, Wu W. Rspo2 is a secreted

activator of Wnt/β-catenin signalling and is required for Xenopus myogenesis. Dev Cell. 2004 Oct; 7(4): 525-34.

6. Mao B, Wu W, Davidson G, Marhold J, Li M, Mechler BM, Delius H, Hoppe D, Stannek P, Walter

C, Glinka A, Niehrs C. Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling. Nature. 2002 Jun 6; 417(6889):664-7.

7. *Mao B, *Wu W, Li Y, Hoppe D, Stannek P, Glinka A, Niehrs C. LDL-receptor-related protein

6 is a receptor for Dickkopf proteins. Nature. 2001 May 17; 411(6835):321-5. (*equal contribution)

8. Wu W, Glinka A, Delius H, Niehrs C. Mutual antagonism between dickkopf1 and dickkopf2

regulates Wnt/beta-catenin signalling. Curr Biol. 2000 Dec 14-28; 10(24):1611-4.

9. Glinka A, Wu W, Delius H, Monaghan AP, Blumenstock C, Niehrs C. Dickkopf-1 is a member

of a new family of secreted proteins and functions in head induction. Nature. 1998 Jan 22; 391(6665): 357-62. (Article）

10. Glinka A, Wu W, Onichtchouk D, Blumenstock C, Niehrs C. Head induction by simultaneous

repression of Bmp and Wnt signalling in Xenopus. Nature. 1997 Oct 2; 389(6650): 517-9.

联系方式：

清华大学生命科学学院，100084 电话：010-62797127/5

E-mail：wwu@mail.tsinghua.edu.cn

谢道昕 博士 教授，博士生导师，教育部长江学者特聘教授，国家杰出青年基金获得者

教育工作经历

2006-现在：清华大学（《百人计划》责任教授）

2002-2006：新加坡分子细胞生物所（信号传导实验室主任，资深科学家） 1999-2002：新加坡农业分子生物所（植物信号传导实验室主任） 新加坡国立大学（兼职助理教授）

1994-1999：英国EastAnglia大学（Senior Research Associate）

1990-1994：英国John Innes研究中心和英国Leicester大学（Research Associate） 1984-1990：中国农科院研究生院（Ph.D.，MSc.）

1983-1984: 湖南棉花科学研究所（Research Assistant） 1979-1983：湖南农学院（BSc.）

主要科研领域与方向

29

生物体蛋白质的 “ 转录 / 翻译 ” 与 “ 降解 ” 是同样重要的命题。人们在 “ 转录和翻译 ” 的研究中取得了众所周知的突破。可以预见, 对蛋白质是如何被特一性降解的研究, 必将对生命科学的发展产生重要影响。

该实验室主要采用植物分子遗传、生物化学、功能基因组和蛋白组学等方法 , 研究蛋白降解途径和植物激素调控植物生长发育及抗性的机理。

代表性论文 1. Xie D, Feys B, James S, Nieto-Rostro M, Turner J. (1998) COI1: an Arabidopsis gene required

for jasmonate-regulated defense and fertility. Science 280:1091-1094.

2. Xu L, Liu F, Lechner E, Genschik P, Crosby W, Ma H, Peng W, Huang D, Xie D. (2002) The

SCF(COI1) ubiquitin-ligase complexes are required for jasmonate response in Arabidopsis. Plant Cell 14:1919-1935.

3. Liu F, Ni W, Griffith M, Huang Z, Chang C, Peng W, Ma H, Xie,D. (2004) The ASK1 and ASK2

Genes Are Essential for Arabidopsis Early Development. Plant Cell 16:5-20.

4. Xiao S, Dai L, Liu L, Wang Z, Peng W, D Xie. (2004) COS1: an Arabidopsis coi1 suppressor

essential for regulation of jasmonate-mediated plant defense and senescence. Plant Cell 16: 1132-42.

5. Ren C, J Pan, W Peng, P Genschik, L Hobbie, H Hellmann, M Estelle, B Gao, J Peng, C Sun,

Xie D (2005) Point mutations in Arabidopsis Cullin1 reveal its essential role in jasmonate response. Plant J 42, 514524.

6. Wang Z, Dai L, Jiang Z, Peng W, Zhang L, Wang G, Xie D. (2005) GmCOI1, a soybean F-box

protein gene, shows ability to mediate jasmonate-regulated plant defense and fertility in Arabidopsis. Mol. Plant-Microbe Interact. 18:1285-1295

7. Lin Z, Griffith M, Li X, Zh Z, Tan L, Fu Y, Zhang W, Wang X, Xie D*, Sun C*. (2007) Origin

of seed shattering in rice(O.sativa L). Planta 226：11-20 (*co-correspondence).

8. Tan L, Li X, Liu F, Sun X, Li C, Zhu Z, Fu Y, Cai H, Wang X, Xie D*, Sun C*. (2008) Control

of a key transition from prostrate to erect growth in rice domestication. Nature Genetics. 40(11):1360-4. (*co-correspondence)

9. Cheng H, Song S, Xiao LT, Soo HM, Cheng ZW, Xie DX* and Peng JR*. (2009). Gibberellin Acts

Through Jasmonate to Control the Expression of MYB21, MYB24 and MYB57 to Promote Stamen Filament Growth in Arabidopsis. PLoS GENETICS . 5(3):e1000440. (*co-correspondence) 10. Xiaoyi Shan, Yongsheng Zhang, Wen Peng, Zhilong Wang, Daoxin Xie. Molecular mechanism for

jasmonate-induction of anthocyanin accumulation in Arabidopsis. Journal of Experimental Botany (in press)

11. Jianbin Yan, Chi Zhang, Min Gu, Zhiyan Bai, Weiguo Zhang, Tiancong Qi, Zhiwei Cheng, Wen

Peng, Haibin Luo, Fajun Nan, Zhao Wang, and Daoxin Xie. The Arabidopsis CORONATINE INSENSITIVE 1 protein is a jasmonate receptor. Plant Cell (in press)

联系方式:

电话：+86-10-62781575 (o) +86-10-62773664 (lab) 传真：+86-10-62781575

E-mail: daoxinlab@tsinghua.edu.cn

30

闫永彬 博士，副研究员，博士生导师

教育工作经历

1992—1997，清华大学精密仪器与机械学系，工学学士学位 1997—2001，清华大学生物科学与技术系，理学硕士和博士学位 2001年8月-今，任清华大学生命科学学院讲师（2001－2004）、副研究员（2004－今）、博士生导师（2008－今）

主要科研领域与研究方向 蛋白质的稳定性和聚集：主要运用生物波谱学研究蛋白质的折叠、错误折叠、聚集和聚集防止的机理，目前主要研究错误折叠和聚集在人类遗传病中的机制；

核糖核酸酶的结构与功能：主要运用生物物理和生物化学手段研究核糖核酸酶的结构与功能，及其在mRNA代谢调控中的作用。

荣誉和奖励

清华大学2007年度学术新人奖

入选教育部2007年度“新世纪优秀人才支持计划”

北京市第五届青年教师教学基本功比赛二等奖、最佳教案奖，2007年

教育部高等学校科学与技术奖（自然科学奖）一等奖，第二完成人，2006年 清华大学第二届青年教师教学基本功比赛一等奖，2006年 入选霍英东教育基金会第十届高等院校青年教师基金，2006年

代表性论文

1. He GJ, Zhang A, Liu WF, Cheng Y, Yan YB*. (2009) Conformational stability and multistate

unfolding of poly(A)-specific ribonuclease. FEBS J. 276: 2849-2860. (* corresponding author)

2. Liu WF, Zhang A, Cheng Y, Zhou HM, Yan YB*. (2009) Allosteric regulation of human

poly(A)-specific ribonuclease by cap and potassium ions. Biochem. Biophys. Res. Commun. 379: 341-345.

3. Feng S, Yan YB*. (2008) Effects of glycerol on the compaction and stability of the wild

type and mutated rabbit muscle creatine kinase. Proteins 71: 844-854.

4. Feng S, Xu Z, Yan YB*. (2008) Blocking creatine kinase refolding by trace amounts of copper

ions. J. Inorg. Biochem. 102: 928-935.

5. Su JT, Kim SH, Yan YB*. (2007) Dissecting the pretransitional conformational changes in

aminoacylase I thermal denaturation. Biophys. J. 92: 578-587.

6. He HW, Feng S, Pang M, Zhou HM, Yan YB*. (2007) Role of the linker between the N- and

C-terminal domains in the stability and folding of rabbit muscle creatine kinase. Int. J. Biochem. Cell Biol. 39: 1816-1827.

7. Feng S, Zhao TJ, Zhou HM, Yan YB*. (2007) Effects of the single point genetic mutation

D54G on muscle creatine kinase activity, structure and stability. Int. J. Biochem. Cell Biol. 39: 392-401. 8. Jiang Y, Yan YB*, Zhou HM*. (2006) Polyvinyl pyrrolidone 40 assists the refolding of bovine

carbonic anhydrase B by accelerating the refolding of the first molten globule intermediate. J. Biol. Chem. 281: 9058-9065.

31

9. Zhao TJ, Sun S, Liu Y, Liu JM, Liu Q, Yan YB*, Zhou HM*. (2006) Regulating the

drought-responsive element (DRE)-mediated signaling pathway by synergic functions of trans-active and trans-inactive DRE binding factors in Brassica napus. J. Biol. Chem. 281: 10752-10759.

10. Yan YB*, Zhang J, He HW, Zhou HM. (2006) Oligomerization and aggregation of bovine

pancreatic ribonuclease A: Characteristic events observed by FTIR spectroscopy. Biophys. J. 90: 2525-2533.

11. Kim SH, Zhang J, Jiang Y, Zhou HM*, Yan YB*. (2006) Assisting the reactivation of guanidine

hydrochloride-denatured aminoacylase by hydroxypropyl cyclodextrins. Biophys. J. 91: 686-693.

12. He HW, Zhang J, Zhou HM, Yan YB*. (2005) Conformational change in the C-terminal domain

is responsible for the initiation of creatine kinase thermal aggregation. Biophys. J. 89: 2650-2658.

13. Zhao TJ, Ou WB, Xie Q, Liu Y, Yan YB*, Zhou HM*. (2005) Catalysis of creatine kinase

refolding by protein disulphide isomerase involves disulphide cross-link and dimer to tetramer switch. J. Biol. Chem. 280: 13470-13476.

14. Meng FG, Hong YK, He HW, Lyubarev AE, Kurganov BI, Yan YB*, Zhou HM*. (2004) Osmophobic

effect of glycerol on irreversible thermal denaturation of rabbit creatine kinase. Biophys. J. 87: 2247-2254.

15. Yan YB*, Wang Q, He HW, Zhou HM. (2004) Protein thermal aggregation involves distinct

regions: sequential events in the heat-induced unfolding and aggregation of hemoglobin. Biophys. J. 86: 1682-1690.

16. Yan YB*, Wang Q, He HW, Hu XY, Zhang RQ, Zhou HM. (2003) Two-dimensional infrared

correlation spectroscopy study of sequential events in the heat-induced unfolding and aggregation process of Myoglobin. Biophys. J. 85: 1959-1967.

联系方式:

100084，清华大学生命科学学院

电 话：010-62783477（办公室），62787115（实验室） 传 真：010-62771597

E-mail：ybyan@mail.tsinghua.edu.cn

俞立 博士 教授 博士生导师

教育工作经历

1994 四川大学生物系微生物专业 学士

2000 北京大学生命科学学院分子生物学专业 博士 2000~2008 美国国立卫生研究院 博士后 2008~至今 清华大学生命科学学院 教授

主要科研领域与方向

综合细胞生物学，生物化学，系统生物学等手段，利用从酵母到小鼠等不同模式生物研究 1）自吞噬在细胞及分子水平上的调控机制 2）细胞程序性死亡3）细胞器的产生，运动的分子机制。

代表性论文

32

1. Yu L, Alva A, Su H, Dutt P, Freundt E, Welsh S, Baehrecke EH, Lenardo MJ. Regulation of

an ATG7-beclin 1 program of autophagic cell death by caspase-8. Science. 2004 Jun 4; 304(5676):1500-2

2. Yu L, Fengyi Wan, Sudeshna Dutta, Sarah Weish, Zhihua Liu, Eric Freundt, Erich. Baehrecke,

and Michael Lenardo Autophagic programmed cell death by selective catalase degradation. PNAS. March 17,2006.

3. Yu L, Mindy C Hebert, Ying Zhang. TGF-beta receptor-activated p 38 MAP kinase mediates

Smad-independent TGF-beta response. EMBO. J 2002 Jul 15; 21(14): 3749-59

4. Yu L, Strandberg L, Lenardo MJ. The selectivity of autophagy and its role in cell death

and survival. Autophagy. 2008 Jul 1; 4(5):567-73

5. Yu L, Lenardo MJ. Immunology. The paracaspase connection. Science. 2003 Nov 28;

302(5650):1515-6

联系方式:

电话：+86-10-62792880

E-mail: liyulab@mail.tsinghua.edu.cn

杨茂君 博士 教授 博士生导师

教育工作经历

1995-1999年就读于吉林大学生物系获学士学位；

1999-2003年于中国协和医科大学生物化学与分子生物学系攻读博士学位； 2004-2008年于美国西南医学研究中心药理系从事博士后研究； 2008年受聘于清华大学生命科学学院担任教授、博士生导师;

实验室的主要研究方向

细胞有丝分裂检查点相关蛋白质的结构与功能研究

癌症发生相关蛋白质的结构与特异性抑制剂的筛选与设计

代表性论文

1. Kang J, Yang M*, Li B, Qi W, Zhang C, Shokat KM, Tomchick DR, Machius M, Yu H.Structure

and substrate recruitment of the human spindle checkpoint kinase Bub1.Mol Cell. 2008 Nov 7;32(3):394-405.PMID: 18995837(The single asterisk indicates equal contributions.) 2. Yang M, Li B, Liu C,Tomchick DR, Machius M, Rizo J, Yu H, Luo X. Structure of the symmetric

Mad2 dimer supports a two-state model for Mad2 regulation in the spindle checkpoint. PLoS Biol. 2008 Mar 4;6(3):e50; PMID: 18318601

3. Yang M, Li B, Tomchick DR, Machius M, Rizo J, Yu H, Luo X. Blockage of Mad2 activation

by p31comet through structural mimicry. Cell. 2007 Nov 16;131(4):744-55;PMID: 18022368 4. Yang M, Szewczuk LM, Culhane JC, Jalili P, Ball HL, Machius M, Cole PA, Yu H. Structural

basis for inhibition of the LSD1 histone demethylase by the antidepressant trans-2-Phenylcyclopropylamine. Biochemistry. 2007 Jun 15; PMID: 17569509

5. Yang M*, Culhane JC*, Szewczuk LM*, Gocke CB, Brautigam CA, Tomchick DR, Machius M, Cole

PA, Yu H. Structural basis of histone demethylation by LSD1 revealed by suicide inactivation. Nat Struct Mol Biol. 2007 May 27. PMID: 17529991(The single asterisk indicates equal contributions.)

33

6. Yang M, Gocke CB, Luo X, Borek D, Tomchick DR, Machius M, Otwinowski Z, Yu H.. Structural

basis for CoREST-dependent demethylation of nucleosomes by the human LSD1 histone demethylase. Mol Cell. 2006 Aug 4;23(3):377-87. PMID: 16885027

7. Yang M, Xu G, Li S, Sun L, Shi N, Zeng W, Pang H, Zhang W, Rao Z. Crystallization and

preliminary crystallographic analysis of the extracellular fragment of FcalphaRI/CD89. Acta Crystallogr D Biol Crystallogr. 2003 Dec;59(Pt 12):2251-3.PMID: 14646085

8. Yang H*, Yang M*, Ding Y*, Liu Y, Lou Z, Zhou Z, Sun L, Mo L, Ye S, Pang H, Gao GF, Anand

K, Bartlam M, Hilgenfeld R, Rao Z. The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor. Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13190-5. PMID: 14585926. (The single asterisk indicates equal contributions.)

9. Yang M, Li S, Liang G, Sun L, Zhang X, Liu N, Pang H, Miao S, Wang L, Rao Z. Crystallization

and preliminary crystallographic analysis of RSB-66, a novel round spermatid-specific protein. Acta Crystallogr D Biol Crystallogr. 2003 Oct;59(Pt 10):1853-5. PMID: 14501136 10. Ding Y*, Xu G*, Yang M*, Yao M, Gao GF, Wang L, Zhang W, Rao Z. Crystal structure of the

ectodomain of human FcalphaRI. J Biol Chem. 2003 Jul 25;278(30):27966-70.PMID: 12783876. (The single asterisk indicates equal contributions.)

11. Yang M, Zhou W, Zhang X, Hu W, Gao F, Pang H, Miao S, Wang L, Rao Z. Crystallization and

preliminary crystallographic analysis of extracellular fragment X3 of YWK-II/APPH: a human sperm membrane protein related to the Alzheimer betaA4-amyloid precursor protein. Acta Crystallogr D Biol Crystallogr. 2003 Mar;59(Pt 3):506-8.PMID: 12595709 ·Yang M, Liu B, Zhang X, Zhou W, Gao F, Pang H, Miao S, Wang L, Rao Z. Crystallization and preliminary crystallographic analysis of a partial extracellular fragment of a sperm membrane protein YWK-II/APPH related to the Alzheimer betaA4-amyloid precursor protein Acta Crystallogr D Biol Crystallogr. 2003 Jan;59(Pt 1):146-9. PMID: 12499552

联系方式:

电话：+86-10-62789400 传真：+86-10-62792736

E-mail: maojunyang@tsinghua.edu.cn

张大鹏 博士 教授 博士生导师

教育工作经历

1977-1982，西北农业大学 学士

1983-1987，法国波尔多第二大学 博士 1987-1989，中国农业大学 博士后

1989-2008，中国农业大学 副教授，教授，博士生导师 2008至今， 清华大学教授

主要研究方向

植物激素脱落酸（ABA）信号转导，以及与ABA信号转导相关联的蛋白质可逆磷酸化。以拟南芥为模式植物，目前正在进行的主要研究工作有：ABA受体ABAR信号感知的分子机制和下游信号转导机制；钙依赖型蛋白激酶（CDPK）家族成员参与ABA信号转导及其分子机制的研究；ABA信号转导其它有关调节子的鉴定。

34

代表性论文 (Correspondence *)

1. Zhang DP* (2007) Signaling to the nucleus with a loaded GUN. Science, 316: 700-701

(Commentary).

2. Zhu SY, Yu XC, Wang XJ, Zhao R, Li Y, Fan RC, Shang Y, Du SY, Wang XF, Wu FQ, Xu YH, Zhang

XY and Zhang DP* (2007) Two calcium-dependent protein kinases, CPK4 and CPK11, regulate abscisic acid signal transduction in Arabidopsis. Plant Cell, 19: 3019-3036.

3. Shen YY, Wang XF, Wu FQ, Du SY, Cao Z, Shang Y, Wang SL, Peng CC, Yu XC, Zhu SY, Fan RC,

Xu YH, Zhang DP* (2006) The Mg-chelatase H subunit is an abscisic acid receptor. Nature 443: 823-826 (Article).

4. Yu XC, Li MJ, Gao GF, Feng HZ, Gen XQ, Peng CC, Zhu SY, Wang XJ, Shen YY, Zhang DP* (2006)

Abscisic acid stimulates a calcium-dependent protein kinase in grape berry. Plant Physiology, 140: 558-579.

5. Zhang XY, Wang XL, Wang XF, Xia GH, Pan QH, Fan RC, Wu FQ, Yu XC, Zhang DP* (2006) A shift

of phloem unloading from symplasmic to apoplasmic pathway is involved in developmental onset of ripening in grape berry. Plant Physiology, 142: 220-232.

6. Zhang LY , Peng YB, Pelleschi ST, Fan Y, Lu YF, Lu YM, Gao XP, Shen YY, Delrot S, Zhang

DP* (2004) Evidence for apoplasmic phloem unloading in developing apple fruit. Plant Physiology, 135: 574-586.

7. Gao XP, Pan QH, Li MJ, Zhang LY, Wang XF, Shen YY, Lu YF, Chen SW, Liang Z, Zhang DP* (2004)

Abscisic acid is involved in the water stress-induced betaine accumulation in pear leaves. Plant and Cell Physiology, 45: 742-750.

8. Peng YB, Lu YF, Zhang DP* (2003) Abscisic acid activates ATPase in developing apple fruit

especially in fruit phloem cells. Plant, Cell and Environment, 26: 1329-1342.

9. Zhang DP*, Wu ZY, Li XY, Zhao ZX (2002) Purification and identification of a 42- kilodolton

abscisic acid-specific-binding protein from epidermis of broad bean leaves. Plant Physiology, 128: 714-725.

10. Zhang DP*, Chen SW, Peng YB, Shen YY (2001) Abscisic acid-specific binding sites in the

flesh of developing apple fruit. Journal of Experimental Botany, 52: 2097-2103.

联系方式:

电话：+86-10-62781956

E-mail: zhangdp@tsinghua.edu.cn

张荣庆 博士 教 授 博士生导师

教育工作经历

1982年，苏州医学院 医学学士 1993年，南京农业大学 博士

现任清华大学教授，生命科学学院副院长，院学术委员会副主任，蛋白质科学教育部重点实验室副主任，清华大学海洋科学与工程研究中心副主任，海洋生物学博士点学科负责人，欧洲海洋生物技术学会会员, 海洋生物技术(国际)杂志编委

主要科研领域与方向

海洋生物化学与分子生物学，重点为海洋生物新功能基因的发现；

35

9. M Liu, Z Wang*, H Li, R Wu, Y Liu, Q Wu: Mitochondrial dysfunction as an early event in the

process of apoptosis induced by Woodfordin I in human leukemia K562 cells. Toxicology and Applied Pharmacology. 194 (2) 141-155 (2004) (cover) 10. M Liu, Z Wang*, R Wu, S Sun, Q Wu: Monitoring all-trans-retinoic acid-induced differentiation

of human acute promyelocytic leukemia NB4 cells by Fourier-transform infrared spectroscopy. Leukemia. 17 1670-1674 (2003)

联系方式： 100084 ，清华大学医学院 TEL： 86-10-62772240, 010-62772241 FAX： 86-10-62772675

E-mail ： tcm@tsinghua.edu.cn

张林琦 教授、博士生导师、长江特聘教授、国家杰出青年基金获得者

教育工作经历

1981-1985，北京师范大学生物系 学士； 1988-1993，英国爱丁堡大学遗传系 博士；

1993-1997，美国纽约大学艾滋病研究中心 博士后；

1997-2007，美国洛克菲勒大学艾滋病研究中心 助理教授、副教授； 2007-至今，清华大学艾滋病综合研究中心 教授、常务副主任。

主要研究方向

艾滋病病毒的致病机理

艾滋病病毒与免疫系统的相互作用关系 抗艾滋病病毒疫苗和药物的研发

抗艾滋病病毒抗体和淋巴细胞免疫反应的研究与应用

代表性研究论文

1. Lu, L., M. Jia, Y. Ma, L. Yang, Z. Chen, D.D. HO, Y. Jiang, and L. Zhang, The Changing

face of HIV in China. Nature, 2008. 455: p. 607-609.

2. He, Y., Y. Xiao, H. Song, Q. Liang, D. Ju, X. Chen, H. Lu, W. Jing, S. Jiang, and L. Zhang,

Design and evaluation of sifuvirtide: a novel HIV-1 fusion inhibitor. J Biol Chem, 2008. 3. Chen, H.Y., M. Di Mascio, A.S. Perelson, D.D. Ho, and L. Zhang, Determination of virus

burst size in vivo using a single-cycle SIV in rhesus macaques. Proc Natl Acad Sci U S A, 2007. 104(48): p. 19079-84.

4. Arron, S.T., R.M. Ribeiro, A. Gettie, R. Bohm, J. Blanchard, J. Yu, A.S. Perelson, D.D.

Ho, and L. Zhang, Impact of thymectomy on the peripheral T cell pool in rhesus macaques before and after infection with simian immunodeficiency virus. Eur J Immunol, 2005. 35(1): p. 46-55.

5. Zhang, L., Z. Chen, Y. Cao, J. Yu, G. Li, W. Yu, N. Yin, S. Mei, L. Li, P. Balfe, T. He,

L. Ba, F. Zhang, H.H. Lin, M.F. Yuen, C.L. Lai, and D.D. Ho, Molecular characterization of human immunodeficiency virus type 1 and hepatitis C virus in paid blood donors and injection drug users in china. J Virol, 2004. 78(24): p. 13591-9.

41

6. Zhang, L., C. Chung, B.S. Hu, T. He, Y. Guo, A.J. Kim, E. Skulsky, X. Jin, A. Hurley,

B. Ramratnam, M. Markowitz, and D.D. Ho, Genetic characterization of rebounding HIV-1 after cessation of highly active antiretroviral therapy. J Clin Invest, 2000. 106(7): p. 839-45.

7. Zhang, L., B. Ramratnam, K. Tenner-Racz, Y. He, M. Vesanen, S. Lewin, A. Talal, P. Racz,

A.S. Perelson, B.T. Korber, M. Markowitz, and D.D. Ho, Quantifying residual HIV-1 replication in patients receiving combination antiretroviral therapy. N Engl J Med, 1999. 340(21): p. 1605-13.

8. Zhang, L., S.R. Lewin, M. Markowitz, H.H. Lin, E. Skulsky, R. Karanicolas, Y. He, X. Jin,

S. Tuttleton, M. Vesanen, H. Spiegel, R. Kost, J. van Lunzen, H.J. Stellbrink, S. Wolinsky, W. Borkowsky, P. Palumbo, L.G. Kostrikis, and D.D. Ho, Measuring recent thymic emigrants in blood of normal and HIV-1-infected individuals before and after effective therapy. J Exp Med, 1999. 190(5): p. 725-32.

9. Zhang, L., T. He, Y. Huang, Z. Chen, Y. Guo, S. Wu, K.J. Kunstman, R.C. Brown, J.P. Phair,

A.U. Neumann, D.D. Ho, and S.M. Wolinsky, Chemokine coreceptor usage by diverse primary isolates of human immunodeficiency virus type 1. J Virol, 1998. 72(11): p. 9307-12. 10. Zhang, L., Y. Huang, T. He, Y. Cao, and D.D. Ho, HIV-1 subtype and second-receptor use.

Nature, 1996. 383(6603): p. 768.

11. Zhang, L., P. MacKenzie, A. Cleland, E.C. Holmes, A.J. Brown, and P. Simmonds, Selection

for specific sequences in the external envelope protein of human immunodeficiency virus type 1 upon primary infection. J Virol, 1993. 67(6): p. 3345-56.

联系方式： 清华大学医学科学楼A209，100084 TEL： 010-62788131； 010-62797732(Fax) E-mail ： zhanglinqi@tsinghua.edu.cn

祁海 博士，特别研究员

教育工作经历

1991-1996，就读于北京医科大学临床医学系，获医学学士学位。

1997-2003，就读于University of Texas Medical Branch，获病理学博士学位。 2003-2009, Postdoctoral fellow, Laboratory of Immunology, NIAID/NIH 2009-至今，清华大学教授。

研究方向与手段：

综合运用分子与细胞免疫学手段、基因工程小鼠模型、以及基于双光子显微镜的活体成像技术，本实验室致力于研究免疫细胞相互作用、黏附、迁徙、以及反应性组织结构生成的机制。我们同时探索这些机制在诸如先天性免疫缺陷及自身免疫病等免疫病理过程中的作用。

代表性论文：

1. Klauschen, F., Ishii, M., Qi, H., Bajenoff M., Egen J.G., Germain, R.N., and

Meier-Schellersheim, M.: Quantifying cellular interaction dynamics in 3-D fluorescence microscopy data. Nature Protocols (in press).

42

2. Klauschen, F., Qi, H., Egen J.G., Germain, R.N., and Meier-Schellersheim, M.:

Computational reconstruction of cell and tissue surfaces for modeling and data analysis. Nature Protocols 4:1006-1012, 2009.

3. Schwartzberg, P.L., Mueller, K.L., Qi, H., and Cannons, J.L.: SLAM receptors and SAP

influence lymphocyte interactions, development and function. Nature Reviews Immunology 9:39-46, 2009.

4. Qi, H.*, Cannons, J.L.*, Kauschen, F., Schwartzberg, P.L., and Germain, R.N.:

SAP-controlled T-B interactions underlie the formation of germinal centers. Nature 455:764-769, 2008. (article)

5. Germain, R.N., Bajénoff, M., Castellino, F., Chieppa, M., Egen, J.G., Huang, A.Y.C.,

Ishii, M., Koo, L.Y., and Qi, H.: Making friends in out-of-the-way places: how cells of the immune system get together and how they conduct their business as revealed by intravital imaging. Immunological Reviews 221:163-181, 2008.

6. Bajénoff, M., Egen, J.G., Qi, H., Huang, A.Y.C., Castellino, F., and Germain, R.N.:

Highways, Byways, and Breadcrumbs: Directing Lymphocyte Traffic in the Lymph Node. Trends in Immunology 28:346-352, 2007.

7. Qi, H., Egen, J.G., Huang, A.Y.C., and Germain, R.N.: Extrafollicular activation of

lymph node B cells by antigen-bearing dendritic cells. Science 312:1672-1676, 2006. 8. Bajénoff, M., Breart, B., Huang, A.Y., Qi, H., Cazareth. J., Braud, V., Germain, R.N.,

and Glaichenhaus, N.: NK cell behavior in lymph nodes revealed by static and real time imaging. Journal of Experimental Medicine 203:619-631, 2006.

9. Germain, R.N., Castellino, F., Chieppa, M., Egen, J.G., Huang, A.Y.C., Koo, L.Y., and

Qi, H.: An extended vision for dynamic high-resolution intravital immune imaging. Seminars in Immunology 17:431-441, 2005.

10. Huang, A.Y., Qi, H., and Germain, R.N.: Illuminating the landscape of in vivo

immunity: insights from dynamic in situ imaging of secondary lymphoid tissues. Immunity 21: 331-339, 2004.

11. Qi, H., Ji, J., Wanasen, N., and Soong, L.: Enhanced replication of -stimulated

murinegLeishmania amazonensis amastigotes in interferon- macrophages: implications for the pathogenesis of cutaneous leishmaniasis. Infection and Immunity 72: 988-995, 2004. 12. Denning, T.L., Qi, H., Konig, R., and Ernst, P.B.: CD4+ Th cells resembling regulatory

T cells that inhibit chronic colitis differentiate in the absence of interactions between CD4 and Class II MHC. Journal of Immunology 171: 2279-2286, 2003.

13. Qi, H., Denning, T.L., and Soong, L.: Differential induction of IL-10 and IL-12 in

dendritic cells by microbial Toll-Like Receptor activators and the skewing of T cell cytokine profiles. Infection and Immunity 71: 3337-3342, 2003.

14. Ji, J., Sun, J., Qi, H., and Soong, L.: Analysis of T helper cell responses during

infection with Leishmania amazonensis. American Journal of Tropical Medicine & Hygiene 66: 338-345, 2002.

15. Long, S.W., Zhang, X-F., Qi, H., Standaert, S., Walker, D. H., and Yu, X-J.: Antigenic

variation of Ehrlichia chaffeensis resulting from differential expression of the 28-kilodalton protein gene family. Infection and Immunity 70: 1824-1831, 2002.

16. Qi, H., Popov, V., and Soong, L.: Leishmania amazonensis-dendritic cell interactions

in vitro and the priming of parasite-specific CD4+ T cells in vivo. Journal of Immunology 167: 4534-4542, 2001.

43

联系方式：清华大学医学院 100084 TEL：+86-10-62796757

E-mail：qihai@mail.tsinghua.edu.cn

刘国松 教授，博士生导师

教育工作经历

1985-1990就读于美国加州大学洛杉矶分校神经生理学专业并获博士学位，1990-1991在美国加州大学洛杉机分校生理科学系神经生理学专业从事博士后研究，1991-1993任研究助理教授，1993-1996在斯坦福大学分子生物和细胞生理系从事博士后研究，1996-2001受聘于麻省理工学院大脑和认知科学系、生物系任助理教授，2001-2005年7月任麻省理工学院大脑和认知科学系、生物系副教授，同期（1996-2005,7）任麻省理工学院Picower学习和记忆中心研究员，2005年至今受聘于德克萨斯大学奥斯汀分校学习与记忆研究中心担任兼职正教授。并于2005年7月入选清华大学“百人计划”、“长江学者特聘教授”，受聘于清华大学医学院担任教授、博士生导师。2006年获国家自然科学基金委重大项目支持和国家973项目支持。

实验室的主要研究方向：

1.神经系统可塑性和神经系统网络形成及优化的研究

2.学习与记忆的基本原理研究及增强记忆和抗脑衰老的新药开发

代表性论文

1. Wilson NR, Kang JS, Leung T, Varoqui H, Murnick JG, Erickson JD, Liu G: Presynaptic Control

of Excitatory Transmission by Vesicular Transporter Expression. J Neurosci 26:6221-6234, 2005

2. Slutsky I, Sadeghpour S, Li B, Liu G: Enhancement of Synaptic Plasticity through

Chronically Reduced Ca2+ Flux during Uncorrelated Activity. Neuron 44:835-849, 2004 3. Liu G: Local structural balance and functional interaction of excitatory and inhibitory

synapses in hippocampal dendrites. Nature Neurosci 7:373-379, 2004

4. Renger JJ, Egles C, Liu G: A developmental switch in neurotransmitter flux enhances

synaptic efficacy by affecting AMPA receptor activation. Neuron 29:469-484, 2001

5. Tang YP, Shimizu E, Dube GR, Rampon C, Kerchner GA, Zhuo M, Liu G, Tsien JZ: Genetic

enhancement of learning and memory in mice. Nature 401:63-69, 1999

6. Liu G, Choi S, Tsien RW: Variability of neurotransmitter concentration and nonsaturation

of postsynaptic AMPA receptors at synapses in hippocampal cultures and slices. Neuron 22:395-409, 1999

7. Liu G, Tsien RW: Properties of synaptic transmission at single hippocampal synaptic

boutons. Nature 375:404-408, 1995

联系方式： 清华大学医学院 100084 TEL： 86-10-62772230

E-mail ： guosong_liu@tsinghua.edu.cn

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孙方霖 教授，博士生导师，长江学者特聘教授，国家杰出青年科学基金获得者

教育工作经历

1968年出生于山东；1993年就读于英国剑桥大学并获博士学位；1997年在美国华盛顿大学（St. Louis）生物系从事博士后研究；2001受聘于瑞士Friedrich Miecher生物医学研究所担任研究组组长（助理教授）；2005年入选清华大学“百人计划”，清华大学医学院担任教授、博士生导师； 2006年回国并获国家自然科学基金委的“国家杰出青年科学基金”；2007年被聘为教育部生命科学（表观遗传学）“长江学者”特聘教授。现担任清华大学医学院学术委员会主任，国家自然科学基金委员会表观遗传重大项目专家组成员（兼副组长）等。

实验室目前主要研究方向：

1）干细胞分化与个体生长发育的表观遗传学；2）癌症形成的表观遗传调控网络。研究采用的动物模型包括果蝇、小鼠及细胞模式系统（如干细胞和肿瘤细胞）。

自1993至今一直从事表观遗传学研究。研究成果分别在学术期刊包括Cell，Nature, Nature Genetics, Genes & Development和PNAS等杂志上发表（第一作者或通讯作者）。

代表性论文

1. Sun F.L., Dean W.L., Kelsey G., Allen N. D. and Reik W. (1997). Transactivation of Igf2

in a mouse model of Beckwith-Wiedemann syndrome. Nature (full article), 389: 809 – 815. 2. Sun F.L and Elgin S.C.R. (1999). Putting boundaries on silence. Cell, 99: 459-6

3. Sun F.L. Cuaycong M.H. Craig C. A. Wallrath L.L. Locke J. and Elgin S.C.R. (2000). The

fourth chromosome of Drosophila melanogaster: interspersed euchromatic and heterochromatic domains. Proc Natl Acad Sci U S A. 97: 5340-45.

4. Sun F.L. Cuaycong M.H. and Elgin S.C.R. (2001). Long-range nucleosome ordering is

associated with gene silencing in Drosophila melanogaster pericentric heterochromatin. Mol. Cell. Biol. 21: 2867-79.

5. Sun FL, Haynes K, Simpson CL, Lee SD, Collins L, Wuller J, Eissenberg JC, Elgin SC (2004).

cis-Acting determinants of heterochromatin formation on Drosophila melanogaster chromosome four. Mol Cell Biol. 24:8210-20.

6. De Lucia F, Ni JQ, Vaillant C, Sun F-L.** (2005). HP1 modulates the transcription of

cell-cycle regulators in Drosophila melanogaster. Nucleic Acids Res. 33: 2852-58. 7. Liu L.-P., Ni J.-Q., Shi Y-D, Oakeley, E. and Sun F-L** (2005). Sex-specific role of

Drosophila HP1 in chromatin and transcription. Nature Genetics 37: 1361-66

8. Ni, J-Q, Liu L-P, Hess D., Rietdorf J.,1 and Sun F-L** (2006). Drosophila ribosomal

proteins are associated with linker histone H1 and suppress gene transcription. Genes & Development 20: 1959-73

联系方式： 100084 ，清华大学医学院 TEL： 86-10-62792720

E-mail： sfl@tsinghua.edu.cn

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