Anti-ABCA1 antibody (ab136452)datasheet_136452

Product DatasheetAnti-ABCA1 antibody ab136452

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Overview

Product name

Description

Tested applications

Species reactivity

ImmunogenAnti-ABCA1 antibodyRabbit polyclonal to ABCA1WBReacts with: MousePredicted to work with: Rat, Chicken, Cynomolgus Monkey, Rhesus monkey, Chinese HamsterRecombinant fragment: DDIFLRVMSR SMPLFMTLAW IYSVAVIIKG IVYEKEARLK

ETMRIMGLDN SILWFSWFIS SLIPLLVSAG LLVVIL, corresponding to amino acids 629–704

of Mouse ABCA1

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Properties

Form

Storage instructions

Storage buffer

Purity

Clonality

Isotype

Research AreasLiquidStore at -20°C.Preservative: 0.05% Sodium azideWhole antiserumPolyclonalIgGNeuroscience Cell Type Marker Glia marker Astrocyte marker

Cardiovascular Lipids / Lipoproteins Lipid Metabolism Cholesterol Metabolism

Signal Transduction Metabolism Lipid metabolism

Cardiovascular Atherosclerosis Lipoprotein metabolism

Cancer Cancer Metabolism Metabolic signaling pathway

Metabolism of lipids and lipoproteins

Metabolism Pathways and Processes Metabolic signaling pathways

Lipid and lipoprotein metabolism Lipid metabolism

Metabolism Pathways and Processes Metabolic signaling pathways

Lipid and lipoprotein metabolism Cholesterol Metabolism

Metabolism Pathways and Processes Metabolic signaling pathways

Lipid and lipoprotein metabolism Lipoprotein metabolism

Metabolism Types of disease Heart disease

Applications

Our Abpromise guarantee covers the use of ab136452 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.Application

WBNotesWB: 1/5000. Predicted molecular weight: 141 kDa.

Target

Function

Tissue specificitycAMP-dependent and sulfonylurea-sensitive anion transporter. Key gatekeeper influencing intracellular cholesteroltransport.Widely expressed, but most abundant in macrophages.

Product DatasheetTissue specificity

Involvement in diseaseWidely expressed, but most abundant in macrophages.Defects in ABCA1 are a cause of high density lipoprotein deficiency type 1 (HDLD1) [MIM:205400]; also known

as analphalipoproteinemia or Tangier disease (TGD). HDLD1 is a recessive disorder characterized by absence of

high density lipoprotein (HDL) cholesterol from plasma, accumulation of cholesteryl esters, premature coronary

artery disease (CAD), hepatosplenomegaly, recurrent peripheral neuropathy and progressive muscle wasting and

weakness.

Defects in ABCA1 are a cause of high density lipoprotein deficiency type 2 (HDLD2) [MIM:604091]; also known

as familial hypoalphalipoproteinemia (FHA). HDLD2 is inherited as autosomal dominant trait. It is characterized

by moderately low HDL cholesterol, predilection toward premature coronary artery disease (CAD) and a reduction

in cellular cholesterol efflux.

Belongs to the ABC transporter superfamily. ABCA family.

Contains 2 ABC transporter domains.

Multifunctional polypeptide with two homologous halves, each containing an hydrophobic membrane-anchoring

domain and an ATP binding cassette (ABC) domain.

Phosphorylation on Ser-2054 regulates phospholipid efflux.

Palmitoylation by DHHC8 is essential for membrane localization.

Membrane.Sequence similaritiesDomainPost-translationalmodificationsCellular localization

Target information above from: UniProt accession O95477 The UniProt Consortium

The Universal Protein Resource (UniProt) in 2010

Nucleic Acids Res. 38:D142-D148 (2010) .

Database linksEntrez Gene: 373945 Chicken

Entrez Gene: 11303 Mouse

Entrez Gene: 313210 Rat

Entrez Gene: 716107 Rhesus monkey

SwissProt: P41233 Mouse

Unigene: 277376 Mouse

Unigene: 148916 Rat

ABC 1 antibody

ABC Transporter 1 antibody

ABC-1 antibody

ABC1 antibody

ABCA 1 antibody

ABCA1 antibody

ABCA1_HUMAN antibody

ATP binding Cassette 1 antibody

ATP binding cassette sub family A ABC1 member 1 antibody

ATP binding cassette sub family A member 1 antibody

ATP binding Cassette Transporter 1 antibody

ATP-binding cassette 1 antibody

ATP-binding cassette sub-family A member 1 antibody

ATP-binding cassette transporter 1 antibody

CERP antibody

Cholesterol efflux regulatory protein antibody

FLJ14958 antibody

HDLDT1 antibody

Membrane bound antibody

MGC164864 antibody

MGC165011 antibody

TD antibody

TGD antibodyAlternative names

Anti-ABCA1 antibody images

Product DatasheetAnti-ABCA1 antibody (ab136452) at 1/5000 dilution+ Baculovirus expressing recombinant ABC

Predicted band size: 141 kDa

Western blot - Anti-ABCA1 antibody (ab136452)

Please note: All products are"FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Our Abpromise to you: Quality guaranteed and expert technical supportAs standardReplacement or refund for products not performing as stated on the datasheet Valid for 12 months from date of delivery** Response to your inquiry within 24 hours

In additionWe provide support in Chinese, English, French, German, Japanese and Spanish Extensive multi-media technical resources to help you We investigate all quality concerns to ensure our products perform to the highest standards If the product does not perform as described on this datasheet, we will offer a refund or replacement. For full details of the Abpromise, please visit /abpromise or contact our technical team.

Terms and conditionsGuarantee only valid for products bought direct from Abcam or one of our authorized distributors **Regional variations to our Abpromise may apply to the following countries: China, Korea, Singapore, Malaysia, Taiwan and Thailand, which operate a 120 day guarantee. Please contact your regional office for further details Antibodies tested only in recombinant samples are not covered for use on endogenous samples. Please check the datasheet for information on tested species"Predicted to react" information on datasheets is based on sequence

homology and provided for reference only"Predicted to react" species are not guaranteed, as they have not been tested Fast Track products are not covered under the Abpromise. Please see Fast Track terms and condition for additional information Abcam biochemicals are novel compounds and we have not tested their biological activity in house. Please use the literature to identify how to use these products effectively. If you require further assistance please contact the scientific support team

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Product Datasheet

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