行政院国家科学委员会专题研究计画成果报告

行政院国家科学委员会专题研究计画成果报告

行政院国家科学委员会专题研究计画成果报告

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行政院国家科学委员会专题研究计画成果报告

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(EKG) (ICP) (MAP) EKG RR-interval EKG PoinCare’ Plot (Glasgow Coma Scale ,GCS)

Poincare’ GCS

PoinCare’ Plot

Abstract

The purpose of this project is to establish a database from the neurosurgical intensive care unit (ICU).We try to create a biomedical simulator by using analysis of these data, and the clinical correlations .In this year, our study focused on the relation between heart rate variability and sympathovagal activity. We design the device to collect patient vital signs such as electrocardiogram (EKG), blood pressure, and ICP. In frequency domain, we use the fast Fourier transform (FFT) to analysis power destiny spectrum and heart rate variability (HRV). In Time domain, we use Poincare’ Plot which is HRV analysis technique to display nonlinear aspects of the interval sequence. Finally, we discussed the relation between HRV and sympathovagal activity. Conclusion: The area of Poincare’ plot had positive correlation with the GCS score. How ever there were no significant difference between ICP and the area of Poincare’ Plot.

Keywords intracranial pressure ,fast Fourier transform,PoinCare’ Plot ,heart rate variability

10-15 3-7

行政院国家科学委员会专题研究计画成果报告

[1]

[2]

Chaos random PoinCare’ Plot 2D X Y PoinCare’ [3-5]

内

(1)

(a)

Philips IntelliVue MP60 (cerebral perfusion pressure, CPP)

BP ICP EKG NI(National Instruments) (DAQ Card) PCMCIA

DAQ card Cable 8 16 (Differential 8 channel Single-end 16 channel) Web Cam (b)

DAQ Card (Sampling rate) (Sampling Theorem)

行政院国家科学委员会专题研究计画成果报告

X_scale S0~S23 … BP ICP EKG MV

(2)

1~2 500Hz BP ICP EKG EKG

(a)

P R RR-interval 500Hz 2 ( ) [6] (b)

(I) SDNN (II)RMSSD Lorenz Plot Poincare’ Plot [3] Poincare’ Plot X RR interval(n) n 1~data number RR(n) Y RR(n+1)

EKG R-R interval

X

2

1

SD1

SD2

(I)

RR interval

行政院国家科学委员会专题研究计画成果报告

M.Tulppo [7] X1 X2 ??

?=??????θθsin cos 21x x ??????????+1cos sin n n RR RR θθ

SD1 SD2 2

11122

1

)(21)

2

1

21

(

)(1SDSD RR RR Var RR RR Var x Var SD n n n n =?=?==++

2222

1

22SDSD SDRR SD ?

= SDRR RR-interval SDSD n RR ?

Π SD1 SD2

(II)

(III) (c)

(power spectral density analysis) RR-interval resampling 2HZ (fast Fourier transform, FFT) (Power Destiny)

(HFP/TP) (LFP/HFP)

[8] (HZ) 0.003

(VLF) 0.003-0.04 (LF) 0.04-0.15 (HF)

0.15-0.4

(1)

12

5

Heart Rate(HR) HR HR Poincare’ 1 HR Poincare’ HR

(a)HRV (b)Poincare’ Plot

行政院国家科学委员会专题研究计画成果报告

(a)HRV (b)Poincare’ Plot

(a)HRV (b)Poincare’ Plot

(GCS) GCS 9~15 LFP/HFP HFP/TP GCS 3 4~8

GCS

HFP/TP

LFP/HFP

3(96data,7 patients) 0.301 0.210 0.845 0.8644~8(10data,2 patients) 0.327 0.196 0.774 0.4309~15(20data,5 patients)

0.204 0.221

1.906 1.597

Poincare’ Plot SD1 SD2 4~8 9~15

Poincare’ Plot

行政院国家科学委员会专题研究计画成果报告

内 Poincare’ 内

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G Furgi ,F

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