5th Asia Pacific ISSX Meeting 2014

5th Asia Pacific ISSX Meeting 2014 May 9-12, 2014 Binhai One Hot Spring Resort, Tianjin China Hosted by: International Society for Study of Xenobiotics (ISSX) Organized by: Chinese Society for Study of Xenobiotics (CSSX) Co-Organized by: Tianjin Institute of Pharmaceutical Research (TIPR) Committee of Pharmaceutical Engineering of Chinese Pharmaceutical Association (CPECPA) Meeting Management: Shanghai MICE Partners Consulting Co., Ltd (SMPC) Meeting Organizing Committee Changxiao Liu, Meeting Co-Chair, Tianjin Institute of Pharmaceutical Research, China Zhuohan Hu, Meeting Co-Chair, Research Institute for Liver Disease, Shanghai, China John Miners, Meeting Co-Chair, Flinders University School of Medicine, Australia Philip Board, Australian National University, Canberra, Australia Min Huang, Sun Yat-sen University, Guangzhou, China Jae-Gook Shin, Inje University, Busan, Republic of Korea Duanyun Si, Tianjin Institute of Pharmaceutical Sciences, Tianjin, China Bill Smith, Pfizer Inc., San Diego, California, USA Jasminder Sahi, GlaxoSmithKline R&D, China Ikumi Tamai, Kanazawa University, Kanazawa, Japan Wichittra Tassaneeyakul, Khon Kaen University, Khon Kaen, Thailand Zhenqing Zhang, Chinese Academy of Military Medical Sciences Dafang Zhong, Shanghai Institute of Materia Medica, Shanghai, China Mingshe Zhu, Bristol-Myers Squibb, Princeton, New Jersey, USA The scientific program, which will run over three days, will comprise two keynote lectures, two award lectures, three workshops, and twelve symposia along with poster sessions. Save the dates and make plans to join us in Tianjin, China! For meeting registration, sponsor and exhibition inquiry, please contact Frank Fung at info@mice-partners.com or visit http://www.cssx.org.cn/2014/APISSX_2014.asp?ID=41 5th Asia Pacific ISSX Meeting Scientific Program

Scientific Program

Day One: Friday, May 9, 2014

17:30-18:00 | Opening and Welcome Remarks

Location: Meeting Centre Lobby, Binhai One Hot Spring Resort, Tianjin China 18:00-18:30 | Sponsored Scientific Lecture Location: Chinese Restaurant Ballroom

Contributions to therapeutic innovation in China by Chinese Academy of Medical Sciences – from PK to PD Dr. Yan Li

18:30-21:00 | Welcome Reception

Location: Chinese Restaurant Ballroom Day Two: Saturday, May 10, 2014 07:00-8:30 | Registration

Location: Meeting Centre Lobby 8:30-9:00 | Opening Remarks Location: Binhai Hall

9:00-10:00 | K1. Keynote Lecture 1: Personalized Medication in China: Current Status and Trends Location: Binhai Hall

Co-chairs: Zhuohan Hu, Research Institute for Liver Diseases, Shanghai, China; Changxiao Liu, Tianjin Institute of Pharmaceutical Research, Tianjin, China

Speaker: Professor Honghao Zhou, Institute of Clinical Pharmacology, Central South China University, Changsha,

China 10:00-10:30 | Refreshment and Posters Review Location: Meeting Centre Foyer

10:30-12:00 | Workshop 1: The Functional Characterization of Transporters Location: Multimedia Room

Co-chairs: Ikumi Tamai, Kanazawa University, Kanazawa, Japan; Kexin Liu, Dalian Medical University, Dalian, China

10:30-11:00 | S1. Species Differences in Drug Transporters Implications in Safety & Efficacy Jasminder Sahi, GlaxoSmithKline R&D, China

11:00-11:30 | S2. Evaluation of Drug Effect on Transporters Regulating Serum Urate Ikumi Tamai, Kanazawa University, Kanazawa, Japan

11:30-12:00 | S3. Drug Transporter Based Pharmacodynamic Screening of Chinese Herbal Medicine Xiulin Yi, Tianjin Institute of Pharmaceutical Sciences

10:30-12:00 | Symposium 1: Genetic Regulation of Drug Metabolising Enzymes Concurrent with Workshop 1 Location: Binhai Hall

Co-chairs: Peter Mackenzie, Flinders University, Bedford Park, Australia; Zhonghui Yuan, Institute of Veterinary Pharmaceuticals, Wuhan, China

10:30-11:00 | S4. PXR: Endo/xeno Dual Sensor that Integrates SGK2 Signaling for Glucogenesis

Masa Negishi, NIH/NIEHS, Research Triangle Park, North Carolina, USA

11:00-11:30 | S5. Regulation of UDP-glucuronosyltransferases in Breast and Prostate Cells: Implications for Cancer

Peter Mackenzie, Flinders University, Bedford Park, Australia

11:30-12:00 | S6. PCB Regulation of Hepatic Nuclear Receptors: Implications for Hepatic Steatosis Russ Prough, University of Louisville School of Medicine, Louisville, Kentucky, USA

12:00-13:00 | Industry Sponsored Symposia

Location: Binhai Hall- Shimadzu & Multimedia Room-Waters 13:00-14:00 | Posters and Exhibitions Location: Meeting Centre Foyer

14:00-15:30 | Symposium 2: Metabolism and Safety of Herbal Medicines and Natural Products – Preclinical/Clinical and Toxicological Significance Location: Binhai Hall

Co-chairs: Changxiao Liu, Tianjin Institute of Pharmaceutical Research, Tianjin, China; Ge Lin, The Chinese University of Hong Kong, Hong Kong, China

14:00-14:30 | S7. Transporters in Drug Safety of Herbal Medicines

Xiaodong Liu, Chinese Pharmaceutical University, Nanjing, China

14:30-15:00 | S8. Translational Science of Herb-drug Interactions: Preclinical to Clinical Soo-Jin Park, Daegu Haany University, Gyeongsan, Korea

15:00-15:30 | S9. Translational Science of Safety of Herbal Medicines and Natural Products: Development of the Mechanism-based Biomonitoring Marker for Clinical Diagnosis Ge Lin, The Chinese University of Hong Kong, Hong Kong, China

14:00-15:30 | Symposium 3: Drug-Drug Interactionss – Mechanisms and Prediction Location: Multimedia Room

Co-chairs: Jianshi Lou, Tianjin Medical University, Tianjin, China; Ling Yang, Dalian Institute of Chemical Physics, CAS, Dalian, China

14:00-14:30 | S10. Application of Physiologically-based Pharmacokinetic Modeling and Simulation in

Prediction of Human PK and Drug-drug Interactions, an Industrial Experience Chuang Lu, Millennium Pharmaceuticals, Takeda Co, Cambridge, Massachusetts, USA

14:30-15:00 | S11. In vitro Prediction of CYP450 Induction: Enzyme/mRNA Induction and Nuclear Receptor Activation

Hongbing Wang, The University of Maryland School of Pharmacy, Baltimore, Maryland, USA

15:00-15:30 | Clinical Drug Interactions through Inhibition of Drug-Metabolizing Enzymes: The Relationship between Substrate, Enzyme and Rate of Reaction Ling Yang, Dalian Institute of Chemical Physics, CAS, Dalian, China

15:30-16:00 | Refreshment and Posters Review Location: Meeting Centre Foyer

16:00-18:00 | Symposium 4: Transporters Location: Multimedia Room

Co-chairs: Jasminder Sahi, GlaxoSmithKline, Shanghai, China; Genfu Chen, Wuxi Apptec, Shanghai, China

16:00-16:30 | S13. OATP Family: Pathophysiological and Pharmacological Roles

Ikumi Tamai, Kanazawa University, Kanazawa, Japan

16:30-17:00 | S14. Leveraging Transporters for the Discovery of CNS drugs Jasminder Sahi, GlaxoSmithKline, Shanghai, China

17:00-17:30 | S15. Human ABC Transporters and Pharmacogenomics Min-Goo Lee, Yonsei University, Seoul, Korea

17:30-18:00 | S16. Amino Acid Transporters in Cancers for Effective and Selective Delivery of Cancer-targeting Agents: Relevance to Cancer Diagnosis and Therapeutics Yoshikatsu Kanai, Osaka University Graduate School of Medicine, Osaka, Japan

16:00-17:30 | Symposium 5: ADME Optimisation in Drug Discovery and Development Location: Binhai Hall

Co-chairs: Bill Smith, Pfizer Inc-La Jolla Labs, San Diego, California, USA; Xiao-dong Liu, China Pharmaceutical University, Nanjing, China

16:00-16:30 | S17. In vitro ADME Approaches in Early Drug Discovery

Yang Sai, Hutchison MediPharma, Shanghai, China

16:30-17:00 | S18. Experiences in the Assessment of DDI Potential during Drug Development: Progress and Challenges

Bill Smith, Pfizer Inc-La Jolla Labs, San Diego, California, USA

17:00-17:30 | S19. ADME Technologies in Drug Discovery and Development Zheming Gu, XenoBiotic Laboratories, Inc., Plainsboro, New Jersey, USA

18:00-20:30 | Banquet

Location: Chinese Restaurant Ballroom Day Three: Sunday, May 11, 2014 08:00-9:00 | Registration

Location: Meeting Centre Lobby

9:00-10:00 | K2. Keynote Lecture 2: Reactive Intermediates versus Covalent Drugs: Similarities and Differences in Chemical Properties and Toxicological Potential Location: Binhai Hall

Co-chairs: John Miners, Flinders University, Bedford Park, Australia; Zhenqing Zhang, Beijing Institute of Pharmacology and Toxicology, Beijing, China Speaker: Tom Baillie, University of Washington, Seattle, Washington, USA 10:00-10:30 | Refreshment and Posters Review Location: Meeting Centre Foyer

10:30-12:00 | Workshop 2: PK-PD Modeling Location: Multimedia Room

Co-chairs: Geoff Tucker, University of Sheffield (Emeritus) and Simcyp Ltd, Sheffield, UK; Xue-hua Jiang, West

China School of Pharmacy, Chengdu, China

10:30-11:00 | S20. Basic Concepts of PK-PD Modelling Jiansong Yang, GlaxoSmithKline, Shanghai, China

11:00-11:30 | S21. PBPK Modelling and its Application in Drug Development Geoff Tucker, University of Sheffield (Emeritus) and Simcyp Ltd, Sheffield, UK 11:30-12:00 | S22. Principles and Practices of POP PK-PD Wei Lu, Beijing University, Beijing, China

10:30-12:00 | Symposium 6: New Approaches for the Study of Drug Disposition Concurrent with Workshop 2 Location: Binhai Hall

Co-chairs: Frank Gonzalez, Laboratory of Metabolism, NCI, NIH, Bethesda, Maryland, USA;

Zack Cheng, AstraZeneca, Shanghai, China

10:30-11:00 | S23. MicroRNAs in Control of Cytochrome P450 Enzyme Mediated Drug Oxidations and Toxicities

Miki Nakajima, Kanazawa University, Kanazawa, Japan

11:00-11:30 | S24. Human Hepatocyte-like Cells and Their Applications Lijian Hui, Shanghai Institute of Biochemistry and Cell Biology, Shanghai, China 11:30-12:00 | S25. Metabolomics in the Study of Drug Metabolism and Toxicity Frank Gonzalez, Laboratory of Metabolism, NCI, NIH, Bethesda, Maryland, USA

12:00-13:00 | Industry Sponsored Symposia

Location: Binhai Hall-Agilent & Multimedia Room-Simulations Plus Inc./Pharmogo 13:00-14:00 | Posters and Exhibitions Location: Meeting Centre Foyer

14:00-15:30 | Poster Oral presentation: 6 speakers Location: Multimedia Room

15:30-16:00 | Refreshment and Posters Review Location: Meeting Centre Foyer

16:00-18:00 | Symposium 7: Herb-Drug Interactions Location: Binhai Hall

Co-chairs: Chuan Li, Shanghai Institute of Materia Medica, Shanghai, China; Xin He, Tianjin University, Tianjin, China

16:00-16:30 | S26. Predicting Herb-drug Interactions via an Integrated in vitro-in silico-in vivo

Approach

Mary Paine, Washington State University, Spokane, Washington, USA

16:30-17:00 | S27. The Genotyping and Phenotyping of Gut Microbiota and its Application for Evaluating Metabolism and Efficacy of Oral Drugs/Herbal Medicines Ru Yan, University of Macau, Macau, China

17:00-17:30 | S28. Potential Herb-drug and Herb-herb Interaction Associated with

Fufang-Danshen-Fang, an Herb Combination for Treatment of Patients with Angina Pectoris Chuan Li, Shanghai Institute of Materia Medica, Shanghai, China

17:30-18:00 | S29. Roles of Efflux Transporters and Metabolizing Enzymes in Herb Induced Hepatotoxicity

Hua Li, Beijing Institute of Pharmacology and Toxicology, Beijing, China

16:00-17:30 | Symposium 8: Advances in Mass Spectrometry–Application to DMPK Science Location: Multimedia Room

Co-chairs: Mingshe Zhu, Bristol-Myers Squibb, Princeton, New Jersey, USA; Duanyan Si, Tianjin Institute of Pharmaceutical Research, Tianjin, China

16:00-16:30 | S30. Unbiased Detection of Totally Unknown Xenobiotics in Complex Biologic Systems

Using High-resolution Mass Spectrometry: Applications in Drug Metabolism and Beyond Mingshe Zhu, Bristol-Myers Squibb, Princeton, New Jersey, USA

16:30-17:00 |S31. Mass Spectrometry Analysis for DMPK Study: from Small Molecule Drugs to Therapeutic Proteins

Jingkai Gu, Research Center for Drug Metabolism of Jilin University, Changchun, China

17:00-17:30 | S32. Elucidating Host-gut Microbiota Modulation of Therapeutic Outcome Using GCMS-based Metabonomics

Eric Chun Yong Chan, National University of Singapore, Singapore

18:00-21:30 | Social Event

Location: Chinese Restaurant Ballroom Day Four: Monday, May 12, 2014 08:00-8:30 | Registration

Location: Meeting Centre Lobby

8:30-10:00 | ISSX Awards Presentations and Lectures

ISSX Asia-Pacific Scientific Achievement Award: Yasushi Yamazoe ISSX Asia-Pacific New Investigator Award: Kazuya Maeda Location: Binhai Hall Chair: Geoff Tucker, University of Sheffield (Emeritus) and Simcyp Ltd, Sheffield, UK 10:00-10:30 | Refreshment and View Posters Location: Meeting Centre Foyer

10:30-12:00 | Workshop 3: DMPK - Regulatory Perspectives Location: Multimedia Room

Co-chairs: Qingli Wang, State Food and Drug Administration, Beijing, China; Wei Tang, CMP, China

10:30-11:00 | S33. Revision of Japanese Guidance on Drug interaction Studies and its Basic Principle

Yasuo Ohno, National Institute of Health Sciences, Tokyo, Japan

11:00-11:30 | S34. ADME Data for IND and NDA Filing in China: Study Design, Experimental Procedures and Data Reporting

Dafang Zhong, Shanghai Institute of Materia Medica, CAS, Shanghai, China

11:30-12:00 | S35. The Role of Ethnicity in Variability in Response to Drugs - A Clinical Pharmacology Perspective

Shiew Mei Huang, USFDA, Silver Spring, Maryland, USA

10:30-12:00 | Symposium 9: Structure-Function Relationships of Cytochromes P450 Concurrent with Workshop 3 Location: Binhai Hall

Co-chairs: Eric Johnson, The Scripps Research Foundation, La Jolla, California, USA; Hongjian Zhang, Suzhou University, Suzhou, China

10:30-11:00 | S36. Probing Cytochrome P450 Structure Function Relationships Using X-ray

Crystallography

Eric Johnson, The Scripps Research Foundation, La Jolla, California, USA

11:00-11:30 | S37. Structure-Function Relationships among the Human CYP4 Enzymes Allan Rettie, University of Washington, Seattle, Washington, USA 11:30-12:00 | S38. Predictive SAR of P450 Enzymes

Yasushi Yamazoe, Food Safety Commission, Cabinet Office, Government of Japan, Tokyo, Japan

12:00-13:00 | Industry Sponsored Symposia

Location: Binhai Hall-Corning & Multimedia Room-XBL China 13:00-14:00 | Posters and Exhibitions Location: Meeting Centre Foyer

14:00-15:30 | Symposium 10: Pharmacogenetics/Genomics: A Regional Perspective Location: Binhai Hall

Co-chairs: Jae-Gook Shin, Inje University, College of Medicine, Busan, Korea; Min Huang, Sun Yat-sen University, Guangzhou, China

14:00-14:30 | S39. Pharmacogenomics of Antiplatelet Therapy in Asian Patients

Ho-Sook Kim, Inje University, College of Medicine, Busan, Korea 14:30-15:00 | S40. HLA Polymorphisms in Asian Populations

Wichittra Tassaneeyakul, Khon Kaen University, Khon Kaen, Thailand

15:00-15:30 | S41. Application of Pharmacogenomics to Personalized Medicine Min Huang, Sun Yat-sen University, Guangzhou, China

14:00-15:30 | Symposium 11: Active and Reactive Metabolites: Considerations for Drug Discovery and Therapeutics

Location: Multimedia Room

Co-chairs: Tom Baillie, University of Washington, Seattle, Washington, USA; Guorong Fan, Second Military Medical University, Shanghai, China

14:00-14:30 | S42. Establishment of Animal Model of Drug-induced Liver Injury – Involvement of

Immune- and Inflammatory-related Factors and P450-mediated Metabolism Tsuyoshi Yokoi, Nagoya University, Nagoya, Japan

14:30-15:00 | S43. Metabolic Activation and Pulmonary Toxicity of Bisbenzylisoquinoline Alkaloids Jiang Zheng, Seattle Children’s Hospital, Seattle, Washington, USA

15:00-15:30 | S44. Reactive Metabolites in Drug Discovery and Development: Approaches and Risk Mitigation

Tom Baillie, University of Washington, Seattle, Washington, USA

15:30-16:00 | Refreshment and View Posters Location: Meeting Centre Foyer

16:00-17:30 | Symposium 12: Novel Aspects of Conjugating (Phase 2) Enzymes Location: Binhai Hall

Co-chairs: John Miners, Flinders University, Bedford Park, Australia; Zhenqing Zhang, Beijing Institute of Pharmacology and Toxicology, Beijing, China

16:00-16:30 | S45. Glucuronidation and Glucosidation as Complementary Metabolic Pathways

John Miners, Flinders University, Bedford Park, Australia

16:30-17:00 | S46. Stereoselectivity in UDP-Glucuronosyltransferase Pharmacogenetics Su Zeng, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China 17:00-17:30 | S47. Novel Functions of Glutathione S-transferases Philip Board, Australia National University, Canberra, Australia

17:30-18:00 | Poster Awards Session & Closing Remarks Location: Binhai Hall

Information for Exhibitors and Sponsors

Thank you for participating in the 5th Asia Pacific ISSX Meeting at Binhai One Hot Spring Resort on May 9-12, 2014! Below you will find information for shipment and install/dismantle of your booth. Frank Fung and MICE Partners will serve as the organizing company for the meeting. Exhibit Booth

The expo will be held on May 10-12, 2014. The exhibits will be located in the main lobby area of the 1st floor of the Meeting Center. Each exhibitor will be supplied with a 2M deep, 3M long by 2.5M high scheme booth, with one table and 2 chairs.

Exhibitors are liable for any damage caused to buildings, floors, walls, and columns or to the shell scheme panels. Exhibitors may not apply paint, lacquer, adhesives or coating to building columns or floors.

All extra requirements, e.g. special decoration, extra lighting, furniture, LCD, plasma TV etc, not provided above, should be ordered separately. They are supplied at extra costs as listed below.

Please note: The exhibit area is not secure. Exhibitors are liable for ensuring their goods and materials are secured and or stored safely. MICE Partners and APISSX 2014 organizers will not be held liable for any vendor materials that may be damaged or missing. Exhibit Hours

Although the layout of the Booth Exposition enables free-access to vendor and booths throughout the conference, the vendors will be required to be at their exhibit space during the following official exhibit hours: May 10-12, 12:00 am - 14:00 pm Sunday, May 11, 12:00 am - 14:00 pm Move-in and Move-out

Move-in: Friday, May 9, 16:00 pm -19:00 pm Move-out: Monday, May 12, 14:00 pm - 17:00 pm

Booths must be setup no later than 8:30 am on Saturday morning. All booths and materials must be dismantled and removed no later than 18:00 pm on Monday. Shipping Instructions

Ship your booth materials to the address to the attention of the Conference Service Manger of the hotel. Materials must arrive by May 5, 2014. Make sure that YOUR COMPANY NAME and APISSX 2014 is clearly marketed on the outside of your shipping packages. APISSX 2014 Organizers and MICE Partners assume no responsibility for items shipped to venue by the sponsor/exhibitor company. It is highly recommended that sponsor/exhibitor company carry all necessary insurance to protect against damage, loss, theft, etc. Please ship your exhibit materials to: Binhai One Hot Spring Resort Tianjin Attn: Miss Jia Liu

NO.188, Jiafeng Road, Tianjin Binhai New Area, Huanggang leisure living area, Tianjin 300459, China Be sure that the following information appears on the outside of your packages: Hold for APISSX 2014 / [Your Company Name] Miss Jia Liu's contact information is as follows:

Cell: 86-15802204773 T 86-22-25228888 F 86-22-25226853 E: liujia@binhaione.com

赞助商或参展商资料邮寄地址：

滨海一号温泉度假酒店

地址：天津滨海新区黄港休闲居住区嘉丰路188号 电话： 86-22-25228888 传真： 86-22-25226908

前台转交刘佳收，手机：15802204773

注意：1.快递包裹外包装上务必写上“APISSX 2014”以及贵公司名称。

2. 请在5月5日左右寄到酒店即可。 Additional Exhibit Options

We are very pleased to provide high-quality services for your exhibit needs. Please select the service you require and contact Frank Fung to place your order. If you have any question, please contact with us at any time.

Item Easy-pull Banner Stand Plasma or LCD TV LCD monitor Projector Laptop Additional Electric Spotlight Specifications 0.8M(W) x 2M(H) 42\17\Sanyo 3000 ANSI with one 100 Screen IBM P4 One (1) 5A/220V socket 100W Quotation RMB400/set RMB1000/set/day RMB500/set/day RMB1200/set/day RMB500/set/day RMB50/set RMB60/set On-site Manager Mr. Frank Fung

Event Service Manager

Shanghai MICE Partners Consulting Co., Ltd.

Rm 411 Zhenxin Biz Bld, No. 2199 South Qilianshan Rd, Shanghai 201824 China E-mail: frank.fung@mice-partners.com

Tel: 86-21-39152015 Mobile: 86-18917509848/13817660578

Posters Session Information

There will be poster session through May 10-12. Authors must be in attendance at their posters during the poster sessions. Also, remember to take any business cards that are in your envelope - these people are requesting reprints of your abstract.

The poster size can be 0.9 meter wide by 2 meter high, or within the size.

May 10: 97 posters (Analytical to Drug Discovery and Development) May 11: 105 posters (Drug Interaction to Metabolism)

May 12: 90 posters (Non-P450 Phase I Enzymes to Transporters)

The set-up time will be 8:00-10:00 for each day; the break-down time will be 18:00-19:00 for each day.

Venue Information

Attendees traveling to the 5th AP-ISSX Meeting 2014 will want to arrive into the Tianjin Binhai International Airport (TSN). The Binhai One Hot Spring Resort, Tianjin is a five-star resort hotel with an integration of accommodation, catering, conference, spa, sports, leisure and health care. It is located at Huanggang ecological innovation and conservation zone within Binhai New Area in Tianjin and at the north of Beitang Toll Station with an advantageous location and convenient transportation.

酒店地处天津市滨海新区黄港休闲居住区，位于京津高速公路北塘收费站北侧，环境优美，出行便利。- 距离塘沽火车站约15.4公里；- 距离天津港客运码头约22.1公里；- 距离天津滨海国际机场约31.3公里；- 距离天津站（东站）约43.7公里。 (Google Map)

If you are from/in Beijing, there will be two ways for you to Tianjin.

1. You can take shuttle bus at Beijing International Airport to Tianjin, please visit http://www.bcia.com.cn/traffic/airbus/ for details.

2. You can take bullet train from Beijing South Railway Station to Tianjin Railway Station. Please visit www.12306.cn for details.

If you are from/in Tianjin, there will be two ways for you to the Binhai One Hot Spring Resort.

1. You can take Subway Line 9, and get off at Tanggu Station. We will arrange shuttle bus there at 10:00am to 17:00pm on May 9. You also can take taxi from Tanggu Station, about RMB 36 to the Resort.

2. You can take taxi from Tianjin International Airport, about RMB 130 to the Resort.

If you are from/in Beijing, there will be two ways for you to Tianjin.

1. You can take shuttle bus at Beijing International Airport to Tianjin, please visit http://www.bcia.com.cn/traffic/airbus/ for details.

2. You can take bullet train from Beijing South Railway Station to Tianjin Railway Station. Please visit www.12306.cn for details.

If you are from/in Tianjin, there will be two ways for you to the Binhai One Hot Spring Resort.

1. You can take Subway Line 9, and get off at Tanggu Station. We will arrange shuttle bus there at 10:00am to 17:00pm on May 9. You also can take taxi from Tanggu Station, about RMB 36 to the Resort.

2. You can take taxi from Tianjin International Airport, about RMB 130 to the Resort.

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