化工文献检索课程卷

化工文献检索

2012~2013学年文献检索课程作业

1.文献检索(邻菲咯啉(phen)衍生物的合成，应用，及配合物制备，晶体结构性质) 关键词:1,10-phenanthroline;complex;crystal structure;coordination compound） 第一篇:化学欧洲-杂志 检索途径：

[1] Wiley-VCH Verlag GmbH Co,KgaA. Concave 1,10-Phenanthrolines as Ligands for Cyclopropanations–Towards a Deeper Understanding of the Stereoselectivity[J]. European Journal of Organic Chemistry, 2009,(14):328-2341

题目：Concave 1,10-Phenanthrolines as Ligands for Cyclopropanations–Towards a Deeper

Understanding of the Stereoselectivity

Abstract :Four new mono- and bimacrocyclic 1,10-phenanthrolines-3b and 4a-ccontaining aryl bridgeheads have been synthesised. The etherification of the aryl bridgeheads was accompl-ished by Williamson or Mitsunobu reactions. A key step in the synthesis of the macr-ocyclic phenanth rolines 3 and 4 is the Suzuki coupling of 2,9-diiodo-1,10-phenanthrolinewith the appropriately sub -stituted boronic acids 17 and 20. Ring-closing metathesis and hydrogenation Completed the synt- hesis. The resulting macrocyclic 1,10-phenanthrolines 3b and 4a–c weretested as ligands in a copp -er(I)-catalysed stereoselective cyclopropanation.

Keywords:Cyclopropanation; Heterocycles; Macrocycles; 1,10-Phenanthr-oline; Supramolecular chemistry

作者：Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 期刊：European Journal of Organic Chemistry；期刊号：Volume 2009, Issue 14, 页码：2328–2341

第二篇：ACS Publications 检索途径：

[2] Anders Foller Larsen,Trond. Efficient Synthesis of 4,7-Diamino Substituted 1,10-Phenan- throline-2,9-dicarboxamides [J],ACS Publishion,2011,（13):6-35484.

题目:Efficient Synthesis of 4,7-Diamino Substituted 1,10-Phenanthroline-2,9-dicarboxam- ides

Abstract :Aconvenient and high-yielding multigram synthesis of the versatile intermediate 4,7-dichloro-1,10-phenanthroline-2,9-dicarboxylic acid is described. The intermediate is further

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化工文献检索

efficiently derivatized to 4,7-diamino-1,10-phenanthroline-2,9-dicarboxamides with potential G-quadruplex stabilizing effects. of Southern Denmark, Campusvej 55, DK-5230 Odense M, DenmarkOrg.

作者：Anders Foller Larsen and Trond UlvenDepartment of Physics and Chemistry, University 期刊：ACS Publishion 期刊号:2011（13），页码:3546-35484. 第三篇：RSC Advance the chemistry Science 检索途径：

[3] Javier Hernández-Gil , Sacramento Ferrer Llusar , Carmen R. Maldonado and Juan C. Mareque-Rivas, Synergy between quantum dots and 1,10-phenanthroline–copper(II) complex towards cleaving DNA[J].Chem. Commun,2011,(47):55-2957

题目：Synergy between quantum dots and 1,10-phenanthroline–copper(II) complex towards

cleaving DNA

Abstract：We have found that the DNA cleaving activity of quantum dots and 1,10-phenant hroline–Cu(II) complex is significantly enhanced when they are combined.。

作者：Javier Hernández-Gil , Sacramento Ferrer Llusar , Carmen R. Maldonado and Juan C. Mareque-Rivas 期刊：Chem Commun, 期刊号：2011,47,页码：2955-2957 第四篇：sciencedirect 检索途径：

[4] Carol Deegan, Barry Coyle, Malachy McCann, Michael Devereux, Denise A. Egan, In vitroanti-tumour effect of 1,10-phenanthroline-5,6-dione (phendione), [Cu(phendione)3]

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(ClO4)2·4H2O and [Ag(phendione)2]ClO4 using human epithelial cell lines[J]. Chemico- Biological Interactions, 2006, 164(1-2):115–125

题目：In vitroanti-tumour effect of 1,10-phenanthroline-5,6-dione (phendione), [Cu(phen- dione)3](ClO4)2·4H2O and [Ag(phendione)2]ClO4 using human epithelial cell lines

Abstract:The anti-cancer chemotherapeutic potential of 1,10-phenanthroline-5,6-dione (phendio

ne), [Cu(phendione)3](ClO4)2·4H2O and [Ag(phendione)2]ClO4 were determined using fourhuman cells lines, ie. two neoplastic (A-498 and Hep-G2) and two non-neoplastic (CHANG and HK-2). All of the phendione derivatives induced a concentration-dependant decrease in the viability of the four cell lines, with [Cu(phendione)3](ClO4)2·4H2O displaying greatest activity. In comparative studies, IC50 values obtained with the two neoplastic cell lines showed a cytotoxic response which was between3and 35times greater than that observed for the metal-based anti-cancer agent, cisplatin. Furthermore, metal–phendione complexes, rather than simple solvated metal ions, were responsible for the observed cytotoxicity. Despite the high level of potency associated with these compounds they did not display an apparent cyto-selective profile, as they reduced the viability of both neoplastic and non-neoplastic cells. However, selected mechanistic studies showed that phendione and its metal complexes inhibited DNA synthesis which did not appear to be mediated through intercalation. Ames testing highlighted that all three compounds and their phase I metabol ites were non-mutagenic, unlike cisplatin. Taken together, these results suggest that phendione and its Cu(II) and Ag(I) complexes may be capable of acting as highly effective anti-cancer ther apies, which with careful administration could provide very potent and effective alternatives to cisplatin.

Keywords：1,10-Phenanthroline-5,6-dione; Transitional metal complexes; DNA inhibition; Anti-cancer potential

作者：Carol Deegan, Barry Coyle, Malachy McCann, Michael Devereux, Denise A. Egan 期刊：Chemico-Biological Interactions 期刊号：Volume 164, Issues 1–2, December 2006, 页码：115–125 第五篇：专利文献 检索途径：

[5] 刘育，喻淼，陈湧. 邻菲咯啉钌环糊精-金刚烷芘-单壁碳纳米管三元超分子体系的制备方法及应用[P].CN200910070083.0,2010-06-09。

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题目：邻菲咯啉钌环糊精-金刚烷芘-单壁碳纳米管三元超分子体系的制备方法及应用 摘要： 本发明属于基于单壁碳纳米管的三元超分子体系制备方法及用途领域，涉及邻菲咯啉钌配合物修饰β-环糊精(邻菲咯啉钌环糊精)-金刚烷修饰芘(金刚烷芘)-单壁碳纳米管三元超分子体系的制备方法及用途。本发明公开了一种邻菲咯啉钌环糊精对单壁碳纳米管的增溶方法及用途。将邻菲咯啉钌环糊精，金刚烷芘和单壁碳纳米管通过超分子组装技术构筑了邻菲咯啉钌环糊精-金刚烷芘-单壁碳纳米管三元超分子体系，得到了单壁碳纳米管的均一分散溶液。同时该三元超分子体系作为一种新型的DNA凝聚试剂，利用钌配合物中邻菲咯啉基团对DNA大小沟槽的嵌入及其正电荷对DNA的凝聚作用，三元超分子体系能有效的对DNA进行凝聚。该方法制备的水溶性邻菲咯啉钌环糊精-金刚烷芘-单壁碳纳米管三元超分子体系在DNA凝聚和基因治疗方面具有重要的应用价值。 作者：刘育，喻淼，陈湧 南开大学 第六篇：硕士论文 检索途径:

[6] 孙冬冬.菲咯啉衍生物、钌(Ⅱ)配合物的抗肿瘤活性及其作用机制[D].广东：广东药学院, 2010.

题目：菲咯啉衍生物、钌(Ⅱ)配合物的抗肿瘤活性及其作用机制

摘要：1.综述了钌配合物的抗肿瘤研究进展及其抗肿瘤作用机制；简单介绍了配合物与DNA作用的理论基础，并阐明钌配合物与DNA分子识别的意义，在此基础上说明了研究目的与依 2.通过改变菲咯啉衍生物上的取代基团及取代基团的位置，设计合成了一系列含多个配位中心的菲咯啉衍生物，希望从构效关系上得出其与抗肿瘤活性的关系。

3.采用MTT法研究菲咯啉衍生物对人肺腺癌A549的抑制作用，流式细胞术研究p-BrPIP诱导A549细胞凋亡，荧光定量PCR, western blot等研究了p-BrPIP作用于A549的抗肿瘤机制，采用溶剂挥发法得到四个菲咯啉衍生物的单晶。结果表明，相同取代基的化合物，其活性顺序是邻位＞对位＞间位；空间位阻大的化合物的活性要弱于位阻小的；荧光定量PCR, western blot等研究结果表明p-BrPIP降低NF-κB的活性通过下调C-myc的表达抑制A549细胞增值。

4．改变配体，合成相应的菲咯啉衍生物具有[(η6-C6H6)RuCl(L)]+的通式(L=菲咯啉衍生物)的芳烃钌(II)配合物13个。运用质谱、核磁等手段对配合物进行了表征。

5.探讨菲咯啉衍生物芳烃钌(II)配合物的抗肿瘤活性及细胞凋亡研究，选用了A549, SMMC

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和SW62三株肿瘤细胞株，采用MTT法研究其抗肿瘤的活性，并分析了配合物9和13诱导A549细胞凋亡作用。结果表明：芳烃钌(II)配合物对A549的抑制作用最强，而对SMMC7721和SW620几乎不具有抑制作用，说明配合物对肿瘤细胞株具有选择性抑制作用；流式细胞术检测结果表明，配合物9和13具有诱导A549细胞凋亡的能力。

关键词：芳烃钌(Ⅱ)配合物，1, 10-邻菲咯啉衍生物，抗肿瘤，MTT，NF-κ 作者：孙冬冬 学位授予单位：广东药学院 学位名称：硕士 学位年度：2010 第七篇：中文期刊 检索途径：

[7] 魏科霞,尹起范,盛振环,朱玉兰,史昆波. 邻菲咯啉衍生物的合成及光谱性质的研究 [J].化学试剂，2010, (2)：165-167

题目：邻菲咯啉衍生物的合成及光谱性质的研究

摘要: 合成了4,5-二氮杂芴-9-酮缩氨基硫脲和4,5-二氮杂芴-9-酮缩氨基脲两种邻菲啉的衍生物。用1HNMR、IR、MS 表征了其结构, 通过紫外可见光谱和荧光光谱研究了其光谱性质, 发现两种新化合物具有良好的荧光特性。 关键词: 1, 10-邻菲啰啉; 衍生物; 合成; 荧光

作者：魏科霞,尹起范,盛振环,朱玉兰,史昆波(淮阴师范学院,化学化工学院,江苏省低维材料化学重点建设实验室,江苏,淮安,223300)韩文霞(延边大学,理学院,吉林,延吉,133002) 刊名: 化学试剂; 期号:第2期 出版日期:2010 第八篇：手工检索

检索途径（CA Chemistry Substrance Index Vol 1215 1994年）

题目：With copper and CAP Protein:DNA Cleavage with copper-Phenanthroline-Catabolite Activator Protein 19897t

摘要：High-specifity DNA deavage agent; design and application to kilobase and megabase DNA substrates. Pendergrast P.shanon;Ebright,Yon W; Ebright,Richard H.Coep.Chem,Rutger Univ;New Brunswick,NJ aggss use,science.(washington,D.C)1994.265(5174),959-62(Eng).endonucleases to cleave double-stranded DNA.at spcific DNA sites longer.than those of restriction endonucleases. (longer than 8 base pairs) have applications in chromosome mapping chromosome cloning and chromosome sequencing-provided that the stralegies yield high DNA-cleavage efficiency and high DNA-cleavage specifity .In this report,the DNA-cleaving moiety copper;o-phenanthor line was attached to the sequence-specific DNA binding protein catabolite,activator-protein (CAP) at an

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