奥曲肽不同给药方式治疗急性胰腺炎的疗效差异研究

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奥曲肽不同给药方式治疗急性胰腺炎的疗效差异研究

作者：龚珍民

来源：《中外医疗》2015年第18期

[摘要] 目的 分析和探讨奥曲肽不同给药方式治疗胰腺炎的疗效差异，为急性胰腺炎的临床治疗寻求最佳治疗方式。 方法 将该院2013年1月—2014年6月收治的98例急性胰腺炎患者随机分为观察组和对照组，每组49例，对照组患者采用普通输液器给药，观察组患者采用微量泵给药，对两组治疗效果进行比较和分析。结果 观察组患者治疗总有效率分别为91.84%及71.43%，患者症状减轻时间分别为（6.4±1.1）、（10.5±2.4）d；淀粉酶恢复时间分别为（18.5±6.5）d及（27.8±9.4）d，住院时间分别为（8.6±1.4）d及（13.8±2.2）d。组间差异均具有统计学意义（P

[关键词] 奥曲肽；不同给药方式；急性胰腺炎；疗效

[中图分类号] R576 [文献标识码] A [文章编号] 1674-0742（2015）06（c）-0110-02 [Abstract] Objective To analyze and discuss the different of curative effect of octreotide in the treatnment of pancreatitis by different modes of administration so as to find out the best one. Methods 98 cases of patients with acute pancreatitis admitted to our hospital From January 2013 to June 2014 were randomly divided into observation group and control group， 49 cases in each group： the control group was treated by ordinary infusion， while observation group were treated by micro pump. The effect of the two groups were analyzed and compared. Results Of the observation group and the control group， the total effective rates were 91.84% and 91.84% respectively， and the patients relieve symptoms （6.4±1.1）d vs（10.5±2.4）d， and amylase recovery time（18.5±6.5）d vs（27.8±9.4）d， and length of hospital stay （8.6±1.4）d vs（13.8±2.2）d. The differences between the groups were statistically significant （P < 0.05）. Conclusion The effect of micro pump infusion of Octreotide in the treatment of acute pancreatitis is remarkable， and it can shorten the recovery time， so it is worthy of widespread clinical application.

[key words] Octreotide； Different ways of drug delivery； Acute pancreatitis； Curative effect 急性胰腺炎因多种病因引起的胰酶提前激活、在周围组织及胰腺中产生自身消化的现象，使组织细胞坏死，从而导致机体局部或全身损伤。急性胰腺炎是临床多发疾病，其主要特点为发病急、进展快，主要临床表现为恶心、呕吐、腹痛等，腹痛较剧烈，多位于左上腹部痛，可绵延至左腰部及左肩，实验室检查可知尿、血胰酶升高[1]。奥曲肽是临床常用的抑制胰酶分泌药物，可有效减轻急性胰腺炎患者的临床症状。该研究整群选取2013年1月—2014年6月

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